RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility.

RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility.

To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility.We reported previously that transgenic mice with cardiac-restricted α1A-AR overexpression (α1A-TG) exhibit enhanced contractility but not hypertrophy, despite evidence implicating this Gαq/11-couple...

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Bibliographic Details
Main Authors: Ze-Yan Yu, Ju-Chiat Tan, Aisling C McMahon, Siiri E Iismaa, Xiao-Hui Xiao, Scott H Kesteven, Melissa E Reichelt, Marion C Mohl, Nicola J Smith, Diane Fatkin, David Allen, Stewart I Head, Robert M Graham, Michael P Feneley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4053326?pdf=render

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