Deguelin Inhibits the Migration and Invasion of U-2 OS Human Osteosarcoma Cells via the Inhibition of Matrix Metalloproteinase-2/-9 in Vitro

Deguelin Inhibits the Migration and Invasion of U-2 OS Human Osteosarcoma Cells via the Inhibition of Matrix Metalloproteinase-2/-9 in Vitro

Osteosarcoma is the most common malignant primary bone tumor in children and young adults and lung metastasis is the main cause of death in those patients. Deguelin, a naturally occurring rotenoid, is known to be an Akt inhibitor and to exhibit cytotoxic effects, including antiproliferative and anti...

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Bibliographic Details
Main Authors: Hung-Sheng Shang, Jin-Biou Chang, Ju-Hwa Lin, Jing-Pin Lin, Shu-Chun Hsu, Chi-Ming Liu, Jia-You Liu, Ping-Ping Wu, Hsu-Feng Lu, Man-Kuan Au, Jing-Gung Chung
Format: Article
Language:English
Published: MDPI AG 2014-10-01
Series:Molecules
Subjects:
deguelin
U-2 OS human osteosarcoma cells
migration
invasion
Online Access:http://www.mdpi.com/1420-3049/19/10/16588

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