Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics
<i>Caenorhabditis elegans</i> is an important model used for many aspects of biological research. Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the biochemical properties of those P450s have been published so far. However, an increasing number of ar...
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| Format: | Article |
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MDPI AG
2022-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/3/342 |
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| author | Lucie Larigot Daniel Mansuy Ilona Borowski Xavier Coumoul Julien Dairou |
| author_facet | Lucie Larigot Daniel Mansuy Ilona Borowski Xavier Coumoul Julien Dairou |
| author_sort | Lucie Larigot |
| collection | DOAJ |
| description | <i>Caenorhabditis elegans</i> is an important model used for many aspects of biological research. Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the biochemical properties of those P450s have been published so far. However, an increasing number of articles have appeared on their involvement in the metabolism of xenobiotics and endobiotics such as fatty acid derivatives and steroids. Moreover, the implication of some P450s in various biological functions of <i>C. elegans</i>, such as survival, dauer formation, life span, fat content, or lipid metabolism, without mention of the precise reaction catalyzed by those P450s, has been reported in several articles. This review presents the state of our knowledge about <i>C. elegans</i> P450s. |
| first_indexed | 2024-03-09T20:04:53Z |
| format | Article |
| id | doaj.art-7cf3f6d1836a4517b4f44cb5962302bf |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:04:53Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7cf3f6d1836a4517b4f44cb5962302bf2023-11-24T00:34:32ZengMDPI AGBiomolecules2218-273X2022-02-0112334210.3390/biom12030342Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of XenobioticsLucie Larigot0Daniel Mansuy1Ilona Borowski2Xavier Coumoul3Julien Dairou4Campus Saint Germain, INSERM UMR-S 1124, Université de Paris, 45 rue des Saints-Pères, 75006 Paris, FranceLaboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, CNRS, Université de Paris, 75006 Paris, FranceLaboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, CNRS, Université de Paris, 75006 Paris, FranceCampus Saint Germain, INSERM UMR-S 1124, Université de Paris, 45 rue des Saints-Pères, 75006 Paris, FranceLaboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, CNRS, Université de Paris, 75006 Paris, France<i>Caenorhabditis elegans</i> is an important model used for many aspects of biological research. Its genome contains 76 genes coding for cytochromes P450 (P450s), and few data about the biochemical properties of those P450s have been published so far. However, an increasing number of articles have appeared on their involvement in the metabolism of xenobiotics and endobiotics such as fatty acid derivatives and steroids. Moreover, the implication of some P450s in various biological functions of <i>C. elegans</i>, such as survival, dauer formation, life span, fat content, or lipid metabolism, without mention of the precise reaction catalyzed by those P450s, has been reported in several articles. This review presents the state of our knowledge about <i>C. elegans</i> P450s.https://www.mdpi.com/2218-273X/12/3/342cytochrome P450worm nematodepredictive toxicologyxenobiotics |
| spellingShingle | Lucie Larigot Daniel Mansuy Ilona Borowski Xavier Coumoul Julien Dairou Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics Biomolecules cytochrome P450 worm nematode predictive toxicology xenobiotics |
| title | Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics |
| title_full | Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics |
| title_fullStr | Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics |
| title_full_unstemmed | Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics |
| title_short | Cytochromes P450 of <i>Caenorhabditis elegans</i>: Implication in Biological Functions and Metabolism of Xenobiotics |
| title_sort | cytochromes p450 of i caenorhabditis elegans i implication in biological functions and metabolism of xenobiotics |
| topic | cytochrome P450 worm nematode predictive toxicology xenobiotics |
| url | https://www.mdpi.com/2218-273X/12/3/342 |
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