The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors
AbstractBackground To investigate the prevalence and related influencing factors of subclinical hypothyroidism (SCH) in a pre-diabetes (PreDM) population.Patients and methods A multi-stage stratified cluster random sampling method was used to select the adult Han population in Gansu Province for inv...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2178668 |
| _version_ | 1827380541577494528 |
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| author | Xingyu Chang Yaqi Wang Yi Liu Yanyu Shen Jiaqing Feng Qianqian Liu Chenjun Jiang Jing Yu Xulei Tang Gaojing Jing Qianglong Niu Songbo Fu |
| author_facet | Xingyu Chang Yaqi Wang Yi Liu Yanyu Shen Jiaqing Feng Qianqian Liu Chenjun Jiang Jing Yu Xulei Tang Gaojing Jing Qianglong Niu Songbo Fu |
| author_sort | Xingyu Chang |
| collection | DOAJ |
| description | AbstractBackground To investigate the prevalence and related influencing factors of subclinical hypothyroidism (SCH) in a pre-diabetes (PreDM) population.Patients and methods A multi-stage stratified cluster random sampling method was used to select the adult Han population in Gansu Province for investigation. General data and related biochemical indices were recorded and SPSS software was used for statistical analyses.Results This study selected 2876 patients, including 548 with SCH and 433 with PreDM. In the PreDM population, the levels of thyroid stimulating hormone (TSH), serum phosphorus, TPOAb and TgAb in the SCH group were higher than those in the euthyroid group (P < 0.05). The level of TPOAb in females of SCH group was higher than that in males (P < 0.05). The positive rates of TPOAb and TgAb in females were higher than those in males in the total population and SCH population. The prevalence of SCH in the PreDM group under 60 was significantly higher than that in the normal glucose tolerance (NGT) group (26.02% vs. 20.40%, χ2 = 5.150, P < 0.05). We defined SCH as a TSH level of >4.20 mIU/L. Using this criterion, the prevalence of SCH in the total population of PreDM was higher than that in the NGT population (χ2 = 8.611, P < 0.05), the prevalence of SCH in the PreDM population generally showed an upward trend. However, we performed a separate analysis considering the accepted impact of age on TSH redefining SCH as TSH >8.86 mIU/L (for individuals over age 65). However, allowing for the expected rise in TSH levels in individuals over age 65, the prevalence of SCH in the elderly over 65 years of age decreased significantly (NGT population from 27.48% to 9.16%, PreDM population from 34.18% to 6.33%, P < 0.05). Logistic regression analysis showed that the risk factors for SCH in the PreDM population were female gender, fasting plasma glucose and TSH (all P < 0.05). Risk factors for SCH in the impaired fasting glucose (IFG) population were female gender, OGTT 2 h, TSH and TPOAb (all P < 0.05).Conclusion The prevalence of SCH in the PreDM population not considering the known physiological increase in age related TSH was relatively high and was significant in female and the IFG population. However, the effect of age on these findings needs to attract more attention. |
| first_indexed | 2024-03-08T13:35:28Z |
| format | Article |
| id | doaj.art-7cf44c201c574e83a52a0d7350bb8acd |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:28Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-7cf44c201c574e83a52a0d7350bb8acd2024-01-16T19:13:20ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-0155164365110.1080/07853890.2023.2178668The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factorsXingyu Chang0Yaqi Wang1Yi Liu2Yanyu Shen3Jiaqing Feng4Qianqian Liu5Chenjun Jiang6Jing Yu7Xulei Tang8Gaojing Jing9Qianglong Niu10Songbo Fu11The First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Endocrinology, First Hospital of Lanzhou University, Lanzhou, ChinaDepartment of Endocrinology, First Hospital of Lanzhou University, Lanzhou, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaAbstractBackground To investigate the prevalence and related influencing factors of subclinical hypothyroidism (SCH) in a pre-diabetes (PreDM) population.Patients and methods A multi-stage stratified cluster random sampling method was used to select the adult Han population in Gansu Province for investigation. General data and related biochemical indices were recorded and SPSS software was used for statistical analyses.Results This study selected 2876 patients, including 548 with SCH and 433 with PreDM. In the PreDM population, the levels of thyroid stimulating hormone (TSH), serum phosphorus, TPOAb and TgAb in the SCH group were higher than those in the euthyroid group (P < 0.05). The level of TPOAb in females of SCH group was higher than that in males (P < 0.05). The positive rates of TPOAb and TgAb in females were higher than those in males in the total population and SCH population. The prevalence of SCH in the PreDM group under 60 was significantly higher than that in the normal glucose tolerance (NGT) group (26.02% vs. 20.40%, χ2 = 5.150, P < 0.05). We defined SCH as a TSH level of >4.20 mIU/L. Using this criterion, the prevalence of SCH in the total population of PreDM was higher than that in the NGT population (χ2 = 8.611, P < 0.05), the prevalence of SCH in the PreDM population generally showed an upward trend. However, we performed a separate analysis considering the accepted impact of age on TSH redefining SCH as TSH >8.86 mIU/L (for individuals over age 65). However, allowing for the expected rise in TSH levels in individuals over age 65, the prevalence of SCH in the elderly over 65 years of age decreased significantly (NGT population from 27.48% to 9.16%, PreDM population from 34.18% to 6.33%, P < 0.05). Logistic regression analysis showed that the risk factors for SCH in the PreDM population were female gender, fasting plasma glucose and TSH (all P < 0.05). Risk factors for SCH in the impaired fasting glucose (IFG) population were female gender, OGTT 2 h, TSH and TPOAb (all P < 0.05).Conclusion The prevalence of SCH in the PreDM population not considering the known physiological increase in age related TSH was relatively high and was significant in female and the IFG population. However, the effect of age on these findings needs to attract more attention.https://www.tandfonline.com/doi/10.1080/07853890.2023.2178668Pre-diabetessubclinical hypothyroidismrisk factors |
| spellingShingle | Xingyu Chang Yaqi Wang Yi Liu Yanyu Shen Jiaqing Feng Qianqian Liu Chenjun Jiang Jing Yu Xulei Tang Gaojing Jing Qianglong Niu Songbo Fu The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors Annals of Medicine Pre-diabetes subclinical hypothyroidism risk factors |
| title | The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors |
| title_full | The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors |
| title_fullStr | The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors |
| title_full_unstemmed | The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors |
| title_short | The prevalence of subclinical hypothyroidism in a pre-diabetes population and an analysis of related factors |
| title_sort | prevalence of subclinical hypothyroidism in a pre diabetes population and an analysis of related factors |
| topic | Pre-diabetes subclinical hypothyroidism risk factors |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2178668 |
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