Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery
Objective: To calculate fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT) by considering the branch flow distribution in the coronary arteries. Background: FFR is the gold standard to diagnose myocardial ischemia caused by coronary stenosis. An accurate and no...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AIMS Press
2021-07-01
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| Series: | Mathematical Biosciences and Engineering |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2021299?viewType=HTML |
| _version_ | 1818850975087067136 |
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| author | Honghui Zhang Jun Xia Yinlong Yang Qingqing Yang Hongfang Song Jinjie Xie Yue Ma Yang Hou Aike Qiao |
| author_facet | Honghui Zhang Jun Xia Yinlong Yang Qingqing Yang Hongfang Song Jinjie Xie Yue Ma Yang Hou Aike Qiao |
| author_sort | Honghui Zhang |
| collection | DOAJ |
| description | Objective:
To calculate fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT) by considering the branch flow distribution in the coronary arteries.
Background:
FFR is the gold standard to diagnose myocardial ischemia caused by coronary stenosis. An accurate and noninvasive method for obtaining total coronary blood flow is needed for the calculation of FFRCT.
Methods:
A mathematical model for estimating the coronary blood flow rate and two approaches for setting the patient-specific flow boundary condition were proposed. Coronary branch flow distribution methods based on a volume-flow approach and a diameter-flow approach were employed for the numerical simulation of FFRCT. The values of simulated FFRCT for 16 patients were compared with their clinically measured FFR.
Results:
The ratio of total coronary blood flow to cardiac output and the myocardial blood flow under the condition of hyperemia were 16.97% and 4.07 mL/min/g, respectively. The errors of FFRCT compared with clinical data under the volume-flow approach and diameter-flow approach were 10.47% and 11.76%, respectively, the diagnostic accuracies of FFRCT were 65% and 85%, and the consistencies were 95% and 90%.
Conclusions:
The mathematical model for estimating the coronary blood flow rate and the coronary branch flow distribution method can be applied to calculate the value of clinical noninvasive FFRCT. |
| first_indexed | 2024-12-19T06:57:40Z |
| format | Article |
| id | doaj.art-7cf453ee35c640c098aa2425c53cf0c2 |
| institution | Directory Open Access Journal |
| issn | 1551-0018 |
| language | English |
| last_indexed | 2024-12-19T06:57:40Z |
| publishDate | 2021-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj.art-7cf453ee35c640c098aa2425c53cf0c22022-12-21T20:31:29ZengAIMS PressMathematical Biosciences and Engineering1551-00182021-07-011855978599410.3934/mbe.2021299Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary arteryHonghui Zhang0Jun Xia1Yinlong Yang2Qingqing Yang3Hongfang Song 4Jinjie Xie 5Yue Ma6Yang Hou7Aike Qiao 81. Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China 2. Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, China1. Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China 2. Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, China1. Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China 2. Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, China1. Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China 2. Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, China3. School of Biomedical Engineering, Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China4. Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China5. Shengjing Hospital, China Medical University, Shenyang 110001, China5. Shengjing Hospital, China Medical University, Shenyang 110001, China1. Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China 2. Intelligent Physiological Measurement and Clinical Translation, Beijing International Base for Scientific and Technological Cooperation, Beijing 100124, ChinaObjective: To calculate fractional flow reserve (FFR) based on computed tomography angiography (i.e., FFRCT) by considering the branch flow distribution in the coronary arteries. Background: FFR is the gold standard to diagnose myocardial ischemia caused by coronary stenosis. An accurate and noninvasive method for obtaining total coronary blood flow is needed for the calculation of FFRCT. Methods: A mathematical model for estimating the coronary blood flow rate and two approaches for setting the patient-specific flow boundary condition were proposed. Coronary branch flow distribution methods based on a volume-flow approach and a diameter-flow approach were employed for the numerical simulation of FFRCT. The values of simulated FFRCT for 16 patients were compared with their clinically measured FFR. Results: The ratio of total coronary blood flow to cardiac output and the myocardial blood flow under the condition of hyperemia were 16.97% and 4.07 mL/min/g, respectively. The errors of FFRCT compared with clinical data under the volume-flow approach and diameter-flow approach were 10.47% and 11.76%, respectively, the diagnostic accuracies of FFRCT were 65% and 85%, and the consistencies were 95% and 90%. Conclusions: The mathematical model for estimating the coronary blood flow rate and the coronary branch flow distribution method can be applied to calculate the value of clinical noninvasive FFRCT.https://www.aimspress.com/article/doi/10.3934/mbe.2021299?viewType=HTMLcoronary artery diseasehemodynamicsendovascular interventioncatheterizationdiagnosis |
| spellingShingle | Honghui Zhang Jun Xia Yinlong Yang Qingqing Yang Hongfang Song Jinjie Xie Yue Ma Yang Hou Aike Qiao Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery Mathematical Biosciences and Engineering coronary artery disease hemodynamics endovascular intervention catheterization diagnosis |
| title | Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_full | Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_fullStr | Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_full_unstemmed | Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_short | Branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| title_sort | branch flow distribution approach and its application in the calculation of fractional flow reserve in stenotic coronary artery |
| topic | coronary artery disease hemodynamics endovascular intervention catheterization diagnosis |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2021299?viewType=HTML |
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