Research progress of aquaporin 1 and 4 in diabetic retinopathy
Diabetic retinopathy(DR), one of the most common retinal vascular disease, is one of the causes of blindness for people over the age of 50. In the early stage of DR, microvascular cells are damaged, expand, start to leak, form micro hemangioma, then show occlusion, and non-perfusion area come into b...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-06-01
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| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2017/6/201706017.pdf |
| _version_ | 1818614142088511488 |
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| author | Xiao-Juan Zhang Nan-Jue Cao Wei Qiang Xiao-Long Chen |
| author_facet | Xiao-Juan Zhang Nan-Jue Cao Wei Qiang Xiao-Long Chen |
| author_sort | Xiao-Juan Zhang |
| collection | DOAJ |
| description | Diabetic retinopathy(DR), one of the most common retinal vascular disease, is one of the causes of blindness for people over the age of 50. In the early stage of DR, microvascular cells are damaged, expand, start to leak, form micro hemangioma, then show occlusion, and non-perfusion area come into being, eventually form new blood vessels because of ischemia and hypoxia of retina. Illness develop into proliferative diabetic retinopathy(PDR). With the aggravation of the disease, PDR can cause the formation of fibrovascular membrane, the more serious fibrillation of epiretinal membrane, resulting in traction retinal detachment(tRD). Present studies suggest that aquaporins, the essential component of new blood vessels, including aquaporin 1 and aquaporin 4, play a significant pole in the development of diabetic retinopathy, causing the destruction of blood retinal barrier, inducing retinal edema, even macular edema, and participating in the formation of retinal angiogenesis. |
| first_indexed | 2024-12-16T16:13:18Z |
| format | Article |
| id | doaj.art-7cf45cdfdebc4bfc9d2537674b739a27 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-16T16:13:18Z |
| publishDate | 2017-06-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-7cf45cdfdebc4bfc9d2537674b739a272022-12-21T22:25:10ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232017-06-011761077108110.3980/j.issn.1672-5123.2017.6.17Research progress of aquaporin 1 and 4 in diabetic retinopathyXiao-Juan Zhang0Nan-Jue Cao1Wei Qiang2Xiao-Long Chen3Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDepartment of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDepartment of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDepartment of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, ChinaDiabetic retinopathy(DR), one of the most common retinal vascular disease, is one of the causes of blindness for people over the age of 50. In the early stage of DR, microvascular cells are damaged, expand, start to leak, form micro hemangioma, then show occlusion, and non-perfusion area come into being, eventually form new blood vessels because of ischemia and hypoxia of retina. Illness develop into proliferative diabetic retinopathy(PDR). With the aggravation of the disease, PDR can cause the formation of fibrovascular membrane, the more serious fibrillation of epiretinal membrane, resulting in traction retinal detachment(tRD). Present studies suggest that aquaporins, the essential component of new blood vessels, including aquaporin 1 and aquaporin 4, play a significant pole in the development of diabetic retinopathy, causing the destruction of blood retinal barrier, inducing retinal edema, even macular edema, and participating in the formation of retinal angiogenesis.http://ies.ijo.cn/cn_publish/2017/6/201706017.pdfdiabetic retinopathyAQP1AQP4AQP4 |
| spellingShingle | Xiao-Juan Zhang Nan-Jue Cao Wei Qiang Xiao-Long Chen Research progress of aquaporin 1 and 4 in diabetic retinopathy Guoji Yanke Zazhi diabetic retinopathy AQP1 AQP4 AQP4 |
| title | Research progress of aquaporin 1 and 4 in diabetic retinopathy |
| title_full | Research progress of aquaporin 1 and 4 in diabetic retinopathy |
| title_fullStr | Research progress of aquaporin 1 and 4 in diabetic retinopathy |
| title_full_unstemmed | Research progress of aquaporin 1 and 4 in diabetic retinopathy |
| title_short | Research progress of aquaporin 1 and 4 in diabetic retinopathy |
| title_sort | research progress of aquaporin 1 and 4 in diabetic retinopathy |
| topic | diabetic retinopathy AQP1 AQP4 AQP4 |
| url | http://ies.ijo.cn/cn_publish/2017/6/201706017.pdf |
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