Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring
Live-attenuated rotavirus vaccine has shown low protection in underdeveloped or developing countries. However, the inactivated rotavirus vaccine may have the potential to overcome some of these challenges. In the present study, the immunogenicity and protective efficacy of a bivalent inactivated rot...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-12-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2021.2011548 |
| _version_ | 1797673249967964160 |
|---|---|
| author | Na Yin Jinyuan Wu Xiangjing Kuang Xiaochen Lin Yan Zhou Shan Yi Xiaoqing Hu Rong Chen Yaling Liu Jun Ye Zhanlong He Maosheng Sun Hongjun Li |
| author_facet | Na Yin Jinyuan Wu Xiangjing Kuang Xiaochen Lin Yan Zhou Shan Yi Xiaoqing Hu Rong Chen Yaling Liu Jun Ye Zhanlong He Maosheng Sun Hongjun Li |
| author_sort | Na Yin |
| collection | DOAJ |
| description | Live-attenuated rotavirus vaccine has shown low protection in underdeveloped or developing countries. However, the inactivated rotavirus vaccine may have the potential to overcome some of these challenges. In the present study, the immunogenicity and protective efficacy of a bivalent inactivated rotavirus vaccine by parenteral administration were elevated in a neonatal rhesus monkey model. A bivalent inactivated rotavirus vaccine containing G1P[8] (ZTR-68 strain) and G9P[8] (ZTR-18 strain) was administered to pregnant rhesus monkeys twice at an interval of 14 days. Neutralizing antibodies against RV strains ZTR-68, ZTR-18, SA11, WA, UK, and Gottfried emerged in pregnant rhesus monkeys and were transplacentally transmitted to the offspring. In the vaccine group, clinical symptoms of diarrhea, viral load in the gut tissue and histopathological changes were significantly reduced in the neonatal rhesus monkeys following oral challenge with the SA11 strain. |
| first_indexed | 2024-03-11T21:42:49Z |
| format | Article |
| id | doaj.art-7cf485391c9b4c1ebef8eecb8d463e29 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T21:42:49Z |
| publishDate | 2021-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-7cf485391c9b4c1ebef8eecb8d463e292023-09-26T12:53:16ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2021-12-0117125656566510.1080/21645515.2021.20115482011548Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspringNa Yin0Jinyuan Wu1Xiangjing Kuang2Xiaochen Lin3Yan Zhou4Shan Yi5Xiaoqing Hu6Rong Chen7Yaling Liu8Jun Ye9Zhanlong He10Maosheng Sun11Hongjun Li12Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeInstitute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical CollegeLive-attenuated rotavirus vaccine has shown low protection in underdeveloped or developing countries. However, the inactivated rotavirus vaccine may have the potential to overcome some of these challenges. In the present study, the immunogenicity and protective efficacy of a bivalent inactivated rotavirus vaccine by parenteral administration were elevated in a neonatal rhesus monkey model. A bivalent inactivated rotavirus vaccine containing G1P[8] (ZTR-68 strain) and G9P[8] (ZTR-18 strain) was administered to pregnant rhesus monkeys twice at an interval of 14 days. Neutralizing antibodies against RV strains ZTR-68, ZTR-18, SA11, WA, UK, and Gottfried emerged in pregnant rhesus monkeys and were transplacentally transmitted to the offspring. In the vaccine group, clinical symptoms of diarrhea, viral load in the gut tissue and histopathological changes were significantly reduced in the neonatal rhesus monkeys following oral challenge with the SA11 strain.http://dx.doi.org/10.1080/21645515.2021.2011548rotavirusbivalent inactivated vaccineparenteral immunizationprotectionneonatal rhesus monkey |
| spellingShingle | Na Yin Jinyuan Wu Xiangjing Kuang Xiaochen Lin Yan Zhou Shan Yi Xiaoqing Hu Rong Chen Yaling Liu Jun Ye Zhanlong He Maosheng Sun Hongjun Li Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring Human Vaccines & Immunotherapeutics rotavirus bivalent inactivated vaccine parenteral immunization protection neonatal rhesus monkey |
| title | Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring |
| title_full | Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring |
| title_fullStr | Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring |
| title_full_unstemmed | Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring |
| title_short | Vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus SA11 infection in the offspring |
| title_sort | vaccination of pregnant rhesus monkeys with inactivated rotavirus as a model for achieving protection from rotavirus sa11 infection in the offspring |
| topic | rotavirus bivalent inactivated vaccine parenteral immunization protection neonatal rhesus monkey |
| url | http://dx.doi.org/10.1080/21645515.2021.2011548 |
| work_keys_str_mv | AT nayin vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT jinyuanwu vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT xiangjingkuang vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT xiaochenlin vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT yanzhou vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT shanyi vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT xiaoqinghu vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT rongchen vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT yalingliu vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT junye vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT zhanlonghe vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT maoshengsun vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring AT hongjunli vaccinationofpregnantrhesusmonkeyswithinactivatedrotavirusasamodelforachievingprotectionfromrotavirussa11infectionintheoffspring |