The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
Introduction: Basal cell carcinoma (BCC) is the most common skin neoplasm reported in human. On the other hand, trichoepithelioma (TE) is a rare, benign tumour of skin adnexa. The differentiation of BCC and TE may be difficult since their morphological findings are similar. In a few studies, it...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5414/10915_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Introduction: Basal cell carcinoma (BCC) is the most common
skin neoplasm reported in human. On the other hand,
trichoepithelioma (TE) is a rare, benign tumour of skin adnexa.
The differentiation of BCC and TE may be difficult since their
morphological findings are similar. In a few studies, it has
been determined that undifferentiated basaloid cells are highly
positively stained with cytokeratin 19.
Aim: The aim of this study was the comparison of cytokeratin
19 expression in cases of BCC and TE.
Materials and Methods: Sections of skin tissues of 17 TE, 25
BCC and 12 non-neoplastic cases were used for cytokeratin 19
(CK19) immunohistochemical staining.
Results: Staining with CK19 of the BCC cases gave 15(60%)
diffuse, 7 (28%) focal and 3 (12%) negative staining. On the
other hand, among TE cases, 2 (12%) gave diffuse, 5 (29%)
focal and 10 (59%) negative staining with CK19. In the nonneoplastic skin tissue samples, while positive staining with
cytokeratin 19 in the outer root sheath of hair follicles and sweat
glands were observed, there was no staining in basal layers.
Conclusion: CK19 expression may be helpful in the differential
diagnosis of BCC and TE especially in small skin biopsy samples
in which morphologic differentiation is difficult. |
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| ISSN: | 2249-782X 0973-709X |