The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma

Introduction: Basal cell carcinoma (BCC) is the most common skin neoplasm reported in human. On the other hand, trichoepithelioma (TE) is a rare, benign tumour of skin adnexa. The differentiation of BCC and TE may be difficult since their morphological findings are similar. In a few studies, it...

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Main Authors: Recep Bedir, Ibrahim Sehitoglu, Cüneyt Yurdakul, Ismail Sayaygin, Pelin Üstüner, Nursel Dilek
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2015-01-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/5414/10915_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf
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author Recep Bedir
Ibrahim Sehitoglu
Cüneyt Yurdakul
Ismail Sayaygin
Pelin Üstüner
Nursel Dilek
author_facet Recep Bedir
Ibrahim Sehitoglu
Cüneyt Yurdakul
Ismail Sayaygin
Pelin Üstüner
Nursel Dilek
author_sort Recep Bedir
collection DOAJ
description Introduction: Basal cell carcinoma (BCC) is the most common skin neoplasm reported in human. On the other hand, trichoepithelioma (TE) is a rare, benign tumour of skin adnexa. The differentiation of BCC and TE may be difficult since their morphological findings are similar. In a few studies, it has been determined that undifferentiated basaloid cells are highly positively stained with cytokeratin 19. Aim: The aim of this study was the comparison of cytokeratin 19 expression in cases of BCC and TE. Materials and Methods: Sections of skin tissues of 17 TE, 25 BCC and 12 non-neoplastic cases were used for cytokeratin 19 (CK19) immunohistochemical staining. Results: Staining with CK19 of the BCC cases gave 15(60%) diffuse, 7 (28%) focal and 3 (12%) negative staining. On the other hand, among TE cases, 2 (12%) gave diffuse, 5 (29%) focal and 10 (59%) negative staining with CK19. In the nonneoplastic skin tissue samples, while positive staining with cytokeratin 19 in the outer root sheath of hair follicles and sweat glands were observed, there was no staining in basal layers. Conclusion: CK19 expression may be helpful in the differential diagnosis of BCC and TE especially in small skin biopsy samples in which morphologic differentiation is difficult.
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spelling doaj.art-7cf7d85dd88944b4a9fa79064ab7e1dc2022-12-21T22:11:44ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2015-01-0191EC01EC0410.7860/JCDR/2015/10915.5414The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and TrichoepitheliomaRecep Bedir0Ibrahim Sehitoglu1Cüneyt Yurdakul2Ismail Sayaygin3Pelin Üstüner4Nursel Dilek5Assistant Professor, Department of Pathology, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey.Assistant Professor, Department of Pathology, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey.Medical Doctor, Department of Pathology, Recep Tayyip Erdogan University, Medical Faculty, Rize, Turkey.Faculty, Department of Pathology, Karadeniz Technical University, Medical Faculty, Trabzon, Turkey.Medical Doctor, Dermatology Clinic, Rize,TURKEY.Assistant Professor, Recep Tayyip Erdogan University, Medical Faculty, Department of Dermatology, Rize /Turkey.Introduction: Basal cell carcinoma (BCC) is the most common skin neoplasm reported in human. On the other hand, trichoepithelioma (TE) is a rare, benign tumour of skin adnexa. The differentiation of BCC and TE may be difficult since their morphological findings are similar. In a few studies, it has been determined that undifferentiated basaloid cells are highly positively stained with cytokeratin 19. Aim: The aim of this study was the comparison of cytokeratin 19 expression in cases of BCC and TE. Materials and Methods: Sections of skin tissues of 17 TE, 25 BCC and 12 non-neoplastic cases were used for cytokeratin 19 (CK19) immunohistochemical staining. Results: Staining with CK19 of the BCC cases gave 15(60%) diffuse, 7 (28%) focal and 3 (12%) negative staining. On the other hand, among TE cases, 2 (12%) gave diffuse, 5 (29%) focal and 10 (59%) negative staining with CK19. In the nonneoplastic skin tissue samples, while positive staining with cytokeratin 19 in the outer root sheath of hair follicles and sweat glands were observed, there was no staining in basal layers. Conclusion: CK19 expression may be helpful in the differential diagnosis of BCC and TE especially in small skin biopsy samples in which morphologic differentiation is difficult.https://jcdr.net/articles/PDF/5414/10915_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdfdifferential diagnosisfollicular germinative cellshair budsimmunohistochemistryskin tumour
spellingShingle Recep Bedir
Ibrahim Sehitoglu
Cüneyt Yurdakul
Ismail Sayaygin
Pelin Üstüner
Nursel Dilek
The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
Journal of Clinical and Diagnostic Research
differential diagnosis
follicular germinative cells
hair buds
immunohistochemistry
skin tumour
title The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
title_full The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
title_fullStr The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
title_full_unstemmed The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
title_short The Importance of Cytokeratin 19 Expression in the Differentiation of Basal Cell Carcinoma and Trichoepithelioma
title_sort importance of cytokeratin 19 expression in the differentiation of basal cell carcinoma and trichoepithelioma
topic differential diagnosis
follicular germinative cells
hair buds
immunohistochemistry
skin tumour
url https://jcdr.net/articles/PDF/5414/10915_CE(Ra)_F(Sh)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf
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