Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity
Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of th...
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MDPI AG
2020-07-01
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| Online Access: | https://www.mdpi.com/2075-1729/10/8/127 |
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| author | Federica Vinciguerra Andrea Tumminia Roberto Baratta Alfredo Ferro Salvatore Alaimo Maria Hagnäs Marco Graziano Riccardo Vigneri Lucia Frittitta |
| author_facet | Federica Vinciguerra Andrea Tumminia Roberto Baratta Alfredo Ferro Salvatore Alaimo Maria Hagnäs Marco Graziano Riccardo Vigneri Lucia Frittitta |
| author_sort | Federica Vinciguerra |
| collection | DOAJ |
| description | Obesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of the MHO phenotype in a cohort of 246 overweight/obese Italian children and adolescents, and to evaluate their characteristics and the role of insulin resistance. Homeostasis model assessment–insulin resistance (HOMA-IR), insulin sensitivity index (ISI), insulinogenic index (IGI) and disposition index (DI) were all calculated from the Oral Glucose Tolerance Test (OGTT). MHO was defined by either: (1) HOMA-IR < 2.5 (MHO-IRes), or (2) absence of the criteria for metabolic syndrome (MHO-MetS). The MHO prevalence, according to MHO-MetS or MHO-IRes criteria, was 37.4% and 15.8%, respectively. ISI was the strongest predictor of the MHO phenotype, independently associated with both MHO-IRes and MHO-MetS. The MHO-MetS group was further subdivided into insulin sensitive or insulin resistant on the basis of HOMA-IR (either < or ≥ 2.5). Insulin sensitive MHO-MetS patients had a better metabolic profile compared to both insulin resistant MHO-MetS and MUO-MetS individuals. These data underscore the relevance of insulin sensitivity to identifying, among young individuals with overweight/obesity, the ones who have a more favorable metabolic phenotype. |
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| last_indexed | 2024-03-10T18:09:10Z |
| publishDate | 2020-07-01 |
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| series | Life |
| spelling | doaj.art-7cf81ffb828048bea24a9ed313fa4a3a2023-11-20T08:16:18ZengMDPI AGLife2075-17292020-07-0110812710.3390/life10080127Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin SensitivityFederica Vinciguerra0Andrea Tumminia1Roberto Baratta2Alfredo Ferro3Salvatore Alaimo4Maria Hagnäs5Marco Graziano6Riccardo Vigneri7Lucia Frittitta8Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, ItalyEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, ItalyDiabetes, Obesity and Dietetic Center, Garibaldi-Nesima Medical Center, 95122 Catania, ItalyBionformatic Unit, Department of Clinical and Experimental Medicine, University of Catania, 95125 Catania, ItalyBionformatic Unit, Department of Clinical and Experimental Medicine, University of Catania, 95125 Catania, ItalyEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, ItalyEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, ItalyEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, ItalyEndocrinology, Department of Clinical and Experimental Medicine, University of Catania, 95122 Catania, ItalyObesity represents a major risk factor for metabolic disorders, but some individuals, “metabolically healthy” (MHO), show less clinical evidence of these complications, in contrast to “metabolically unhealthy” (MUO) individuals. The aim of this cross-sectional study is to assess the prevalence of the MHO phenotype in a cohort of 246 overweight/obese Italian children and adolescents, and to evaluate their characteristics and the role of insulin resistance. Homeostasis model assessment–insulin resistance (HOMA-IR), insulin sensitivity index (ISI), insulinogenic index (IGI) and disposition index (DI) were all calculated from the Oral Glucose Tolerance Test (OGTT). MHO was defined by either: (1) HOMA-IR < 2.5 (MHO-IRes), or (2) absence of the criteria for metabolic syndrome (MHO-MetS). The MHO prevalence, according to MHO-MetS or MHO-IRes criteria, was 37.4% and 15.8%, respectively. ISI was the strongest predictor of the MHO phenotype, independently associated with both MHO-IRes and MHO-MetS. The MHO-MetS group was further subdivided into insulin sensitive or insulin resistant on the basis of HOMA-IR (either < or ≥ 2.5). Insulin sensitive MHO-MetS patients had a better metabolic profile compared to both insulin resistant MHO-MetS and MUO-MetS individuals. These data underscore the relevance of insulin sensitivity to identifying, among young individuals with overweight/obesity, the ones who have a more favorable metabolic phenotype.https://www.mdpi.com/2075-1729/10/8/127metabolically healthy obesityinsulin resistancemetabolic syndromeadolescentschildren |
| spellingShingle | Federica Vinciguerra Andrea Tumminia Roberto Baratta Alfredo Ferro Salvatore Alaimo Maria Hagnäs Marco Graziano Riccardo Vigneri Lucia Frittitta Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity Life metabolically healthy obesity insulin resistance metabolic syndrome adolescents children |
| title | Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity |
| title_full | Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity |
| title_fullStr | Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity |
| title_full_unstemmed | Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity |
| title_short | Prevalence and Clinical Characteristics of Children and Adolescents with Metabolically Healthy Obesity: Role of Insulin Sensitivity |
| title_sort | prevalence and clinical characteristics of children and adolescents with metabolically healthy obesity role of insulin sensitivity |
| topic | metabolically healthy obesity insulin resistance metabolic syndrome adolescents children |
| url | https://www.mdpi.com/2075-1729/10/8/127 |
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