Blood platelet research in autism spectrum disorders: In search of biomarkers
Abstract Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for autism. None of them have delivered the...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-10-01
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| Series: | Research and Practice in Thrombosis and Haemostasis |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rth2.12239 |
| _version_ | 1797709481464823808 |
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| author | Manisha Padmakumar Eveline Van Raes Chris Van Geet Kathleen Freson |
| author_facet | Manisha Padmakumar Eveline Van Raes Chris Van Geet Kathleen Freson |
| author_sort | Manisha Padmakumar |
| collection | DOAJ |
| description | Abstract Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for autism. None of them have delivered the holy grail that represents a reproducible, quantifiable, and sensitive biomarker. Though blood platelets are mainly known to prevent bleeding, they also play pivotal roles in cancer, inflammation, and neurological disorders. Platelets could serve as a peripheral biomarker or cellular model for autism as they share common biological and molecular characteristics with neurons. In particular, platelet‐dense granules contain neurotransmitters such as serotonin and gamma‐aminobutyric acid. Molecular players controlling granule formation and secretion are similarly regulated in platelets and neurons. The major platelet integrin receptor αIIbβ3 has recently been linked to ASD as a regulator of serotonin transport. Though many studies revealed associations between platelet markers and ASD, there is an important knowledge gap in linking these markers with autism and explaining the altered platelet phenotypes detected in autism patients. The present review enumerates studies of different biomarkers detected in ASD using platelets and highlights the future needs to bring this research to the next level and advance our understanding of this complex disorder. |
| first_indexed | 2024-03-12T06:37:09Z |
| format | Article |
| id | doaj.art-7cf875eacf8e4a6285b3871d84c30ed2 |
| institution | Directory Open Access Journal |
| issn | 2475-0379 |
| language | English |
| last_indexed | 2024-03-12T06:37:09Z |
| publishDate | 2019-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Research and Practice in Thrombosis and Haemostasis |
| spelling | doaj.art-7cf875eacf8e4a6285b3871d84c30ed22023-09-03T01:13:48ZengElsevierResearch and Practice in Thrombosis and Haemostasis2475-03792019-10-013456657710.1002/rth2.12239Blood platelet research in autism spectrum disorders: In search of biomarkersManisha Padmakumar0Eveline Van Raes1Chris Van Geet2Kathleen Freson3Department of Cardiovascular Sciences Center for Molecular and Vascular Biology KU Leuven Leuven BelgiumDepartment of Cardiovascular Sciences Center for Molecular and Vascular Biology KU Leuven Leuven BelgiumDepartment of Cardiovascular Sciences Center for Molecular and Vascular Biology KU Leuven Leuven BelgiumDepartment of Cardiovascular Sciences Center for Molecular and Vascular Biology KU Leuven Leuven BelgiumAbstract Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder that is caused by gene‐environment interactions. To improve its diagnosis and treatment, numerous efforts have been undertaken to identify reliable biomarkers for autism. None of them have delivered the holy grail that represents a reproducible, quantifiable, and sensitive biomarker. Though blood platelets are mainly known to prevent bleeding, they also play pivotal roles in cancer, inflammation, and neurological disorders. Platelets could serve as a peripheral biomarker or cellular model for autism as they share common biological and molecular characteristics with neurons. In particular, platelet‐dense granules contain neurotransmitters such as serotonin and gamma‐aminobutyric acid. Molecular players controlling granule formation and secretion are similarly regulated in platelets and neurons. The major platelet integrin receptor αIIbβ3 has recently been linked to ASD as a regulator of serotonin transport. Though many studies revealed associations between platelet markers and ASD, there is an important knowledge gap in linking these markers with autism and explaining the altered platelet phenotypes detected in autism patients. The present review enumerates studies of different biomarkers detected in ASD using platelets and highlights the future needs to bring this research to the next level and advance our understanding of this complex disorder.https://doi.org/10.1002/rth2.12239autism spectrum disordersblood plateletsgamma‐aminobutyric acidintegrin αIIbβ3melatoninneurotransmitter agents |
| spellingShingle | Manisha Padmakumar Eveline Van Raes Chris Van Geet Kathleen Freson Blood platelet research in autism spectrum disorders: In search of biomarkers Research and Practice in Thrombosis and Haemostasis autism spectrum disorders blood platelets gamma‐aminobutyric acid integrin αIIbβ3 melatonin neurotransmitter agents |
| title | Blood platelet research in autism spectrum disorders: In search of biomarkers |
| title_full | Blood platelet research in autism spectrum disorders: In search of biomarkers |
| title_fullStr | Blood platelet research in autism spectrum disorders: In search of biomarkers |
| title_full_unstemmed | Blood platelet research in autism spectrum disorders: In search of biomarkers |
| title_short | Blood platelet research in autism spectrum disorders: In search of biomarkers |
| title_sort | blood platelet research in autism spectrum disorders in search of biomarkers |
| topic | autism spectrum disorders blood platelets gamma‐aminobutyric acid integrin αIIbβ3 melatonin neurotransmitter agents |
| url | https://doi.org/10.1002/rth2.12239 |
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