Treatment of Behcet’s disease
Behcet’s disease is a systemic disease classified among vasculitides. Major manifestations are mucous membrane lesions (oral aphthosis and genital aphthosis), skin manifestations (pseudofolliculitis, erythema nodosum), ocular manifestations (uveitis, retinal vasculitis), joint manifestations, vascul...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2013-01-01
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| Series: | Chronic Diseases Journal |
| Subjects: | |
| Online Access: | http://cdjournal.muk.ac.ir/index.php/cdj/article/view/20 |
| _version_ | 1797967516177268736 |
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| author | Fereydoun Davatchi Nasrin Moghimi Mohammad Mousavi Alimohammad Fatemi |
| author_facet | Fereydoun Davatchi Nasrin Moghimi Mohammad Mousavi Alimohammad Fatemi |
| author_sort | Fereydoun Davatchi |
| collection | DOAJ |
| description | Behcet’s disease is a systemic disease classified among vasculitides. Major manifestations are mucous membrane lesions (oral aphthosis and genital aphthosis), skin manifestations (pseudofolliculitis, erythema nodosum), ocular manifestations (uveitis, retinal vasculitis), joint manifestations, vascular lesions (small to large vessel thrombosis, aneurysm), gastrointestinal manifestations, orchiepididymitis, and some rare manifestations like cardiac, pulmonary, and renal impairment. Diagnosis is mainly clinical. The International Diagnosis Criteria for Behcet’s Disease may be of help. The gold standard of treatment for mucocutaneous lesions is colchicine. In refractory cases, levamisole, thalidomide, and dapsone may be of help. For major organ involvement like the eyes and the brain, immunosuppressive drugs and prednisolone are the gold standard. In refractory cases, biological agents are the last resort. For gastrointestinal manifestations, sulfasalazine and prednisolone are the first-line treatment. For vascular involvement, the first line treatment was anticoagulation, but recently it was shown that immunosuppressive drugs and prednisolone were confirmed to be the best. In all refractory cases and for all different organs, the last resort is biological agents. |
| first_indexed | 2024-04-11T02:32:25Z |
| format | Article |
| id | doaj.art-7cf92e18f5014e868631262c48dca8c7 |
| institution | Directory Open Access Journal |
| issn | 2345-2226 2345-2226 |
| language | English |
| last_indexed | 2024-04-11T02:32:25Z |
| publishDate | 2013-01-01 |
| publisher | Vesnu Publications |
| record_format | Article |
| series | Chronic Diseases Journal |
| spelling | doaj.art-7cf92e18f5014e868631262c48dca8c72023-01-02T21:09:56ZengVesnu PublicationsChronic Diseases Journal2345-22262345-22262013-01-0111425410.22122/cdj.v1i1.20Treatment of Behcet’s diseaseFereydoun Davatchi0Nasrin Moghimi1Mohammad Mousavi2Alimohammad Fatemi3Professor, Division of Rheumatology, Shariati Hospital AND Behcet’s Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Rheumatology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj AND Behcet’s Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Rheumatology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord AND Behcet’s Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranAssistant Professor, Department of Rheumatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan AND Behcet’s Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, IranBehcet’s disease is a systemic disease classified among vasculitides. Major manifestations are mucous membrane lesions (oral aphthosis and genital aphthosis), skin manifestations (pseudofolliculitis, erythema nodosum), ocular manifestations (uveitis, retinal vasculitis), joint manifestations, vascular lesions (small to large vessel thrombosis, aneurysm), gastrointestinal manifestations, orchiepididymitis, and some rare manifestations like cardiac, pulmonary, and renal impairment. Diagnosis is mainly clinical. The International Diagnosis Criteria for Behcet’s Disease may be of help. The gold standard of treatment for mucocutaneous lesions is colchicine. In refractory cases, levamisole, thalidomide, and dapsone may be of help. For major organ involvement like the eyes and the brain, immunosuppressive drugs and prednisolone are the gold standard. In refractory cases, biological agents are the last resort. For gastrointestinal manifestations, sulfasalazine and prednisolone are the first-line treatment. For vascular involvement, the first line treatment was anticoagulation, but recently it was shown that immunosuppressive drugs and prednisolone were confirmed to be the best. In all refractory cases and for all different organs, the last resort is biological agents.http://cdjournal.muk.ac.ir/index.php/cdj/article/view/20Behcet’s DiseaseTreatmentManifestationDiagnosis |
| spellingShingle | Fereydoun Davatchi Nasrin Moghimi Mohammad Mousavi Alimohammad Fatemi Treatment of Behcet’s disease Chronic Diseases Journal Behcet’s Disease Treatment Manifestation Diagnosis |
| title | Treatment of Behcet’s disease |
| title_full | Treatment of Behcet’s disease |
| title_fullStr | Treatment of Behcet’s disease |
| title_full_unstemmed | Treatment of Behcet’s disease |
| title_short | Treatment of Behcet’s disease |
| title_sort | treatment of behcet s disease |
| topic | Behcet’s Disease Treatment Manifestation Diagnosis |
| url | http://cdjournal.muk.ac.ir/index.php/cdj/article/view/20 |
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