Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases?
Brain CT has been recommended in staging of patients with lung cancer because of its usefulness in the detection of metastases. Purpose of this study is to examine if a diagnostic brain CT (CT1) can be obviated when an integrated PET/CT (PET/CT ) is available. 87 consecutive patients underwent a dia...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ubiquity Press
2010-02-01
|
| Series: | Journal of the Belgian Society of Radiology |
| Subjects: | |
| Online Access: | https://www.jbsr.be/articles/122 |
| _version_ | 1828356149286535168 |
|---|---|
| author | W De Wever E Bruyeer Ph Demaerel G Wilms J Coolen J Verschakelen |
| author_facet | W De Wever E Bruyeer Ph Demaerel G Wilms J Coolen J Verschakelen |
| author_sort | W De Wever |
| collection | DOAJ |
| description | Brain CT has been recommended in staging of patients with lung cancer because of its usefulness in the detection of metastases. Purpose of this study is to examine if a diagnostic brain CT (CT1) can be obviated when an integrated PET/CT (PET/CT ) is available. 87 consecutive patients underwent a diagnostic brain CT and a whole-body PET/CT within a period of 3 weeks to stage a known primary tumour. CT examinations were evaluated by two experienced neuroradiologists on the detection of brain lesions (benign and malignant). The results of PET/CT and CT reading were compared and both readings were compared with the clinical results. Statistical analysis was done by measuring sensitivity, specificity, PPV, NPV and accuracy. The relative accuracies were compared by a McNemar (exact) test for correlated proportions. Considering the CT1 as standard of reference, sensitivity, specificity, PPV, NPV and accuracy for the brain CT of PET/CT (CT2) and PET/CT were respectively 83%, 96%, 77%, 97%, 94% and 69%, 98%, 90%, 95%, 94%. Considering the clinical diagnosis as standard of reference these figures were for CT1, CT2 and PET/CT respectively 80%, 100%, 100%, 96%, 96% and 66%, 95%, 77%, 93%, 90% and 66%, 97%, 83%, 93%, 91%. There was no statistical difference between CT1 and CT2. The comparison of the additional CT in PET/CT with a diagnostic CT of the brain did not yield a statistical difference in the detection of brain lesions despite the inferior quality of the CT component of PET/CT. A diagnostic brain CT can be obviated when a PET/CT is available. |
| first_indexed | 2024-04-14T02:54:50Z |
| format | Article |
| id | doaj.art-7cfa5578bf3b4ca1ac08f00decbede46 |
| institution | Directory Open Access Journal |
| issn | 2514-8281 |
| language | English |
| last_indexed | 2024-04-14T02:54:50Z |
| publishDate | 2010-02-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of the Belgian Society of Radiology |
| spelling | doaj.art-7cfa5578bf3b4ca1ac08f00decbede462022-12-22T02:16:10ZengUbiquity PressJournal of the Belgian Society of Radiology2514-82812010-02-01932717610.5334/jbr-btr.122122Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases?W De WeverE BruyeerPh DemaerelG WilmsJ CoolenJ VerschakelenBrain CT has been recommended in staging of patients with lung cancer because of its usefulness in the detection of metastases. Purpose of this study is to examine if a diagnostic brain CT (CT1) can be obviated when an integrated PET/CT (PET/CT ) is available. 87 consecutive patients underwent a diagnostic brain CT and a whole-body PET/CT within a period of 3 weeks to stage a known primary tumour. CT examinations were evaluated by two experienced neuroradiologists on the detection of brain lesions (benign and malignant). The results of PET/CT and CT reading were compared and both readings were compared with the clinical results. Statistical analysis was done by measuring sensitivity, specificity, PPV, NPV and accuracy. The relative accuracies were compared by a McNemar (exact) test for correlated proportions. Considering the CT1 as standard of reference, sensitivity, specificity, PPV, NPV and accuracy for the brain CT of PET/CT (CT2) and PET/CT were respectively 83%, 96%, 77%, 97%, 94% and 69%, 98%, 90%, 95%, 94%. Considering the clinical diagnosis as standard of reference these figures were for CT1, CT2 and PET/CT respectively 80%, 100%, 100%, 96%, 96% and 66%, 95%, 77%, 93%, 90% and 66%, 97%, 83%, 93%, 91%. There was no statistical difference between CT1 and CT2. The comparison of the additional CT in PET/CT with a diagnostic CT of the brain did not yield a statistical difference in the detection of brain lesions despite the inferior quality of the CT component of PET/CT. A diagnostic brain CT can be obviated when a PET/CT is available.https://www.jbsr.be/articles/122Lung neoplasmsmetastases – Brain neoplasmssecondary - BrainCT |
| spellingShingle | W De Wever E Bruyeer Ph Demaerel G Wilms J Coolen J Verschakelen Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases? Journal of the Belgian Society of Radiology Lung neoplasms metastases – Brain neoplasms secondary - Brain CT |
| title | Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases? |
| title_full | Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases? |
| title_fullStr | Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases? |
| title_full_unstemmed | Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases? |
| title_short | Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases? |
| title_sort | staging of lung cancer do we need a diagnostic ct of the brain after an integrated pet ct for the detection of brain metastases |
| topic | Lung neoplasms metastases – Brain neoplasms secondary - Brain CT |
| url | https://www.jbsr.be/articles/122 |
| work_keys_str_mv | AT wdewever stagingoflungcancerdoweneedadiagnosticctofthebrainafteranintegratedpetctforthedetectionofbrainmetastases AT ebruyeer stagingoflungcancerdoweneedadiagnosticctofthebrainafteranintegratedpetctforthedetectionofbrainmetastases AT phdemaerel stagingoflungcancerdoweneedadiagnosticctofthebrainafteranintegratedpetctforthedetectionofbrainmetastases AT gwilms stagingoflungcancerdoweneedadiagnosticctofthebrainafteranintegratedpetctforthedetectionofbrainmetastases AT jcoolen stagingoflungcancerdoweneedadiagnosticctofthebrainafteranintegratedpetctforthedetectionofbrainmetastases AT jverschakelen stagingoflungcancerdoweneedadiagnosticctofthebrainafteranintegratedpetctforthedetectionofbrainmetastases |