The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns
Background Low birth weight (LBW) in neonates is a problem leading to high morbidity and mortality. Barker hypothesized that fetal cardiac remodeling during hypoxic conditions or maternal undernutrition is a risk factor for coronary heart disease in the young. Early vascular changes may influence c...
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| Format: | Article |
| Language: | English |
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Indonesian Pediatric Society Publishing House
2011-06-01
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| Series: | Paediatrica Indonesiana |
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| Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/720 |
| _version_ | 1818042917859622912 |
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| author | Anindita Soetadji Najib Advani Asril Aminullah Sudigdo Sastroasmoro |
| author_facet | Anindita Soetadji Najib Advani Asril Aminullah Sudigdo Sastroasmoro |
| author_sort | Anindita Soetadji |
| collection | DOAJ |
| description | Background Low birth weight (LBW) in neonates is a problem leading to high morbidity and mortality. Barker hypothesized that fetal cardiac remodeling during hypoxic conditions or maternal undernutrition is a risk factor for coronary heart disease in the
young. Early vascular changes may influence cardiac function and newborns' cerebral blood flow.
Objective The aim of this study was to detennine the effects of being small for gestational age (SGA) on newborns' cardiac function, left ventricular (LV) mass and superior vena cava (SYC) return.
Methods This crosssectional study was conducted in Cipto Mangunkusumo Hospital from February to June 2008. LBW and nonnal newborns who fulfilled the inclusion criteria were recruited as subjects. Maternal history, infant physical examination, and echocardiography were obtained Mthin 48 hours oflife to exclude those with congenital heart disease, and assess cardiac function and SYC flow.
Results Subjects were 21 preterm appropriate for gestational age (AGA), 19 SGA and 19 normal newborns. SGA newborns showed lower LV mass, stroke volume and cardiac output than normal newborns. However, these SGA parameters were not different from preterm AGA babies. In additio n, LV mass index was sig nificantly different but no difference ofSVC return between the three groups.
Conclusion SGA newborns' LV function was lower than that of nonnal newborns, as low as pretenn AGA newborns. N onnal SVC return was observed in the three groups. This finding may be due to a brainsparing effect to maintain sufficient cerebral blood flow
in the fetus. |
| first_indexed | 2024-12-10T08:53:56Z |
| format | Article |
| id | doaj.art-7cfb93099e914a8cb8eb47d0d9aa239b |
| institution | Directory Open Access Journal |
| issn | 0030-9311 2338-476X |
| language | English |
| last_indexed | 2024-12-10T08:53:56Z |
| publishDate | 2011-06-01 |
| publisher | Indonesian Pediatric Society Publishing House |
| record_format | Article |
| series | Paediatrica Indonesiana |
| spelling | doaj.art-7cfb93099e914a8cb8eb47d0d9aa239b2022-12-22T01:55:29ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2011-06-01513170710.14238/pi51.3.2011.170-7587The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newbornsAnindita Soetadji0Najib Advani1Asril Aminullah2Sudigdo Sastroasmoro3Department of Child Health, Diponegoro Univetsity Medical School/Dr. Kariadi Hospital, Semarang, Central JavaDepartment of Child Health University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Child Health University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, JakartaDepartment of Child Health University of Indonesia Medical School/Dr. Cipto Mangunkusumo Hospital, JakartaBackground Low birth weight (LBW) in neonates is a problem leading to high morbidity and mortality. Barker hypothesized that fetal cardiac remodeling during hypoxic conditions or maternal undernutrition is a risk factor for coronary heart disease in the young. Early vascular changes may influence cardiac function and newborns' cerebral blood flow. Objective The aim of this study was to detennine the effects of being small for gestational age (SGA) on newborns' cardiac function, left ventricular (LV) mass and superior vena cava (SYC) return. Methods This crosssectional study was conducted in Cipto Mangunkusumo Hospital from February to June 2008. LBW and nonnal newborns who fulfilled the inclusion criteria were recruited as subjects. Maternal history, infant physical examination, and echocardiography were obtained Mthin 48 hours oflife to exclude those with congenital heart disease, and assess cardiac function and SYC flow. Results Subjects were 21 preterm appropriate for gestational age (AGA), 19 SGA and 19 normal newborns. SGA newborns showed lower LV mass, stroke volume and cardiac output than normal newborns. However, these SGA parameters were not different from preterm AGA babies. In additio n, LV mass index was sig nificantly different but no difference ofSVC return between the three groups. Conclusion SGA newborns' LV function was lower than that of nonnal newborns, as low as pretenn AGA newborns. N onnal SVC return was observed in the three groups. This finding may be due to a brainsparing effect to maintain sufficient cerebral blood flow in the fetus.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/720low birth weightcardiac functionSVC return |
| spellingShingle | Anindita Soetadji Najib Advani Asril Aminullah Sudigdo Sastroasmoro The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns Paediatrica Indonesiana low birth weight cardiac function SVC return |
| title | The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns |
| title_full | The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns |
| title_fullStr | The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns |
| title_full_unstemmed | The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns |
| title_short | The influence of intrauterine growth retardation on cardiac function, left ventricular mass and superior vena cava return in newborns |
| title_sort | influence of intrauterine growth retardation on cardiac function left ventricular mass and superior vena cava return in newborns |
| topic | low birth weight cardiac function SVC return |
| url | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/720 |
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