Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster
Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispens...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01707-w |
| _version_ | 1818681763978805248 |
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| author | Sandro Holzer Jiangyu Yan Mairi L. Kilkenny Stephen D. Bell Luca Pellegrini |
| author_facet | Sandro Holzer Jiangyu Yan Mairi L. Kilkenny Stephen D. Bell Luca Pellegrini |
| author_sort | Sandro Holzer |
| collection | DOAJ |
| description | Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispensable for primer synthesis. |
| first_indexed | 2024-12-17T10:08:08Z |
| format | Article |
| id | doaj.art-7cfdb2fe31884bb48802905f35b30707 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:08:08Z |
| publishDate | 2017-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7cfdb2fe31884bb48802905f35b307072022-12-21T21:53:07ZengNature PortfolioNature Communications2041-17232017-11-018111310.1038/s41467-017-01707-wPrimer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S clusterSandro Holzer0Jiangyu Yan1Mairi L. Kilkenny2Stephen D. Bell3Luca Pellegrini4Department of Biochemistry, University of CambridgeMolecular and Cellular Biochemistry Department, Indiana UniversityDepartment of Biochemistry, University of CambridgeMolecular and Cellular Biochemistry Department, Indiana UniversityDepartment of Biochemistry, University of CambridgePrimase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispensable for primer synthesis.https://doi.org/10.1038/s41467-017-01707-w |
| spellingShingle | Sandro Holzer Jiangyu Yan Mairi L. Kilkenny Stephen D. Bell Luca Pellegrini Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster Nature Communications |
| title | Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster |
| title_full | Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster |
| title_fullStr | Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster |
| title_full_unstemmed | Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster |
| title_short | Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster |
| title_sort | primer synthesis by a eukaryotic like archaeal primase is independent of its fe s cluster |
| url | https://doi.org/10.1038/s41467-017-01707-w |
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