Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster

Primer synthesis by a eukaryotic-like archaeal primase is independent of its Fe-S cluster

Primase is the specialised DNA-dependent RNA polymerase responsible for the initiation of DNA synthesis during DNA replication. Here the authors use a structural biology approach to identify the initiation site in the S. solfataricus PriSLX primase and to demonstrate that its Fe-S cluster is dispens...

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Bibliographic Details
Main Authors: Sandro Holzer, Jiangyu Yan, Mairi L. Kilkenny, Stephen D. Bell, Luca Pellegrini
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01707-w

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