Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients
Pancreatic cancer (PC) is an aggressive disease with a high mortality and poor prognosis. The human microbiome is a key factor in many malignancies, having the ability to alter host metabolism and immune responses and participate in tumorigenesis. Gut microbes have an influence on physiological func...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/23/12978 |
| _version_ | 1797507713951858688 |
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| author | Heidelinde Sammallahti Arto Kokkola Sama Rezasoltani Reza Ghanbari Hamid Asadzadeh Aghdaei Sakari Knuutila Pauli Puolakkainen Virinder Kaur Sarhadi |
| author_facet | Heidelinde Sammallahti Arto Kokkola Sama Rezasoltani Reza Ghanbari Hamid Asadzadeh Aghdaei Sakari Knuutila Pauli Puolakkainen Virinder Kaur Sarhadi |
| author_sort | Heidelinde Sammallahti |
| collection | DOAJ |
| description | Pancreatic cancer (PC) is an aggressive disease with a high mortality and poor prognosis. The human microbiome is a key factor in many malignancies, having the ability to alter host metabolism and immune responses and participate in tumorigenesis. Gut microbes have an influence on physiological functions of the healthy pancreas and are themselves controlled by pancreatic secretions. An altered oral microbiota may colonize the pancreas and cause local inflammation by the action of its metabolites, which may lead to carcinogenesis. The mechanisms behind dysbiosis and PC development are not completely clear. Herein, we review the complex interactions between PC tumorigenesis and the microbiota, and especially the question, whether and how an altered microbiota induces oncogenomic changes, or vice versa, whether cancer mutations have an impact on microbiota composition. In addition, the role of the microbiota in drug efficacy in PC chemo- and immunotherapies is discussed. Possible future scenarios are the intentional manipulation of the gut microbiota in combination with therapy or the utilization of microbial profiles for the noninvasive screening and monitoring of PC. |
| first_indexed | 2024-03-10T04:52:22Z |
| format | Article |
| id | doaj.art-7d00e8275b534c0688fb993150aa4147 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:52:22Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7d00e8275b534c0688fb993150aa41472023-11-23T02:31:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122231297810.3390/ijms222312978Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer PatientsHeidelinde Sammallahti0Arto Kokkola1Sama Rezasoltani2Reza Ghanbari3Hamid Asadzadeh Aghdaei4Sakari Knuutila5Pauli Puolakkainen6Virinder Kaur Sarhadi7Department of Pathology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandDepartment of Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, FinlandFoodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 1985717411, IranDigestive Oncology Research Center, Digestive Diseases Research Institute, Tehran University of Medical Science, Tehran P.O. Box 1411713135, IranBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 1985717411, IranDepartment of Pathology, Faculty of Medicine, University of Helsinki, 00014 Helsinki, FinlandDepartment of Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, FinlandDepartment of Oral and Maxillofacial Diseases, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, FinlandPancreatic cancer (PC) is an aggressive disease with a high mortality and poor prognosis. The human microbiome is a key factor in many malignancies, having the ability to alter host metabolism and immune responses and participate in tumorigenesis. Gut microbes have an influence on physiological functions of the healthy pancreas and are themselves controlled by pancreatic secretions. An altered oral microbiota may colonize the pancreas and cause local inflammation by the action of its metabolites, which may lead to carcinogenesis. The mechanisms behind dysbiosis and PC development are not completely clear. Herein, we review the complex interactions between PC tumorigenesis and the microbiota, and especially the question, whether and how an altered microbiota induces oncogenomic changes, or vice versa, whether cancer mutations have an impact on microbiota composition. In addition, the role of the microbiota in drug efficacy in PC chemo- and immunotherapies is discussed. Possible future scenarios are the intentional manipulation of the gut microbiota in combination with therapy or the utilization of microbial profiles for the noninvasive screening and monitoring of PC.https://www.mdpi.com/1422-0067/22/23/12978pancreatic cancerpancreatic ductal adenocarcinomamicrobiotadysbiosisoncogenomicsmutations |
| spellingShingle | Heidelinde Sammallahti Arto Kokkola Sama Rezasoltani Reza Ghanbari Hamid Asadzadeh Aghdaei Sakari Knuutila Pauli Puolakkainen Virinder Kaur Sarhadi Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients International Journal of Molecular Sciences pancreatic cancer pancreatic ductal adenocarcinoma microbiota dysbiosis oncogenomics mutations |
| title | Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients |
| title_full | Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients |
| title_fullStr | Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients |
| title_full_unstemmed | Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients |
| title_short | Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients |
| title_sort | microbiota alterations and their association with oncogenomic changes in pancreatic cancer patients |
| topic | pancreatic cancer pancreatic ductal adenocarcinoma microbiota dysbiosis oncogenomics mutations |
| url | https://www.mdpi.com/1422-0067/22/23/12978 |
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