HIV-1 pseudoviruses constructed in China regulatory laboratory
ABSTRACTTo better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compare...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2019.1702479 |
| _version_ | 1797265810947833856 |
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| author | Jianhui Nie Weijin Huang Qiang Liu Youchun Wang |
| author_facet | Jianhui Nie Weijin Huang Qiang Liu Youchun Wang |
| author_sort | Jianhui Nie |
| collection | DOAJ |
| description | ABSTRACTTo better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compared with the standard pseudovirus panels derived from other countries/regions, the Chinese isolates are more susceptible to neutralization by the sera obtained in China, revealing the strain/subtype specificity. Some of these pseudoviruses have already been used for the evaluation of HIV vaccines and drug candidates in Chinese clinical trials. The pseudoviruses panel is widely shared with interested scientists involved in the research and development of vaccines and antiviral drugs against HIV-1 strains prevalent in China. |
| first_indexed | 2024-03-07T17:24:05Z |
| format | Article |
| id | doaj.art-7d016566bc8746e592653c0000919836 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-25T00:50:43Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-7d016566bc8746e592653c00009198362024-03-11T16:04:25ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-0191324110.1080/22221751.2019.1702479HIV-1 pseudoviruses constructed in China regulatory laboratoryJianhui Nie0Weijin Huang1Qiang Liu2Youchun Wang3Division of HIV/AIDS and Sexually Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaDivision of HIV/AIDS and Sexually Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaDivision of HIV/AIDS and Sexually Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaDivision of HIV/AIDS and Sexually Transmitted Virus Vaccines, National Institutes for Food and Drug Control (NIFDC), Beijing, People’s Republic of ChinaABSTRACTTo better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compared with the standard pseudovirus panels derived from other countries/regions, the Chinese isolates are more susceptible to neutralization by the sera obtained in China, revealing the strain/subtype specificity. Some of these pseudoviruses have already been used for the evaluation of HIV vaccines and drug candidates in Chinese clinical trials. The pseudoviruses panel is widely shared with interested scientists involved in the research and development of vaccines and antiviral drugs against HIV-1 strains prevalent in China.https://www.tandfonline.com/doi/10.1080/22221751.2019.1702479HIV-1pseudovirusneutralization assaydrug-resistancemutation |
| spellingShingle | Jianhui Nie Weijin Huang Qiang Liu Youchun Wang HIV-1 pseudoviruses constructed in China regulatory laboratory Emerging Microbes and Infections HIV-1 pseudovirus neutralization assay drug-resistance mutation |
| title | HIV-1 pseudoviruses constructed in China regulatory laboratory |
| title_full | HIV-1 pseudoviruses constructed in China regulatory laboratory |
| title_fullStr | HIV-1 pseudoviruses constructed in China regulatory laboratory |
| title_full_unstemmed | HIV-1 pseudoviruses constructed in China regulatory laboratory |
| title_short | HIV-1 pseudoviruses constructed in China regulatory laboratory |
| title_sort | hiv 1 pseudoviruses constructed in china regulatory laboratory |
| topic | HIV-1 pseudovirus neutralization assay drug-resistance mutation |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2019.1702479 |
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