Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins

Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins

Summary: Vascular morphogenesis requires a delicate gradient of Notch signaling controlled, in part, by the distribution of ligands (Dll4 and Jagged1). How Jagged1 (JAG1) expression is compartmentalized in the vascular plexus remains unclear. Here, we show that Jag1 mRNA is a direct target of zinc-f...

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Bibliographic Details
Main Authors: Hannah L. Sunshine, Andrew C. Cicchetto, Karolina Elżbieta Kaczor-Urbanowicz, Feiyang Ma, Danielle Pi, Chloe Symons, Martin Turner, Vipul Shukla, Heather R. Christofk, Thomas A. Vallim, M. Luisa Iruela-Arispe
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723016388

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