Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder
Background & aims In response to limited research on early language development in infants at high risk for Autism Spectrum Disorder (ASD), the current prospective study examined early expressive and receptive language trajectories in familial high-risk (HR) infants who were and were not later d...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-11-01
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| Series: | Autism and Developmental Language Impairments |
| Online Access: | https://doi.org/10.1177/2396941517737418 |
| _version_ | 1797329802071375872 |
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| author | Julie Longard Jessica Brian Lonnie Zwaigenbaum Eric Duku Chris Moore Isabel M Smith Nancy Garon Peter Szatmari Tracy Vaillancourt Susan Bryson |
| author_facet | Julie Longard Jessica Brian Lonnie Zwaigenbaum Eric Duku Chris Moore Isabel M Smith Nancy Garon Peter Szatmari Tracy Vaillancourt Susan Bryson |
| author_sort | Julie Longard |
| collection | DOAJ |
| description | Background & aims In response to limited research on early language development in infants at high risk for Autism Spectrum Disorder (ASD), the current prospective study examined early expressive and receptive language trajectories in familial high-risk (HR) infants who were and were not later diagnosed with ASD (HR-ASD and HR-N, respectively), and low-risk (LR) controls with no family history of ASD. Methods Participants were 523 children (371 HR siblings, 56% boys; 152 LR controls, 52% boys) followed from age 6 or 12 months to 36 months. Based on independent, best-estimate clinical diagnoses at 36 months, HR participants were classified as HR-ASD (n = 94; 69% boys), or HR-N (n = 277; 52% boys); the sample also included 152 LR controls (52% boys). Expressive and receptive language trajectories were examined based on corresponding domain standard scores on the Mullen Scales of Early Learning ( MSEL ) at 6, 12, 24, and 36 months. In the combined sample of HR and LR infants, semi-parametric group-based modeling was used to identify distinct trajectories in MSEL standard scores. Results A 3-group solution provided optimal fit to variation in both expressive and receptive language, with the following patterns of scores: (1) inclining from average to above average, (2) stable-average, and (3) declining from average to well below average. For both expressive and receptive language, membership in these trajectories was related to 3-year diagnostic outcomes. Conclusions Although HR-ASD, HR-N, and LR control infants were in each trajectory group, membership in the declining trajectory (expressive and/or receptive) was associated with an ASD diagnosis. Implications Evidence of declining trajectories in either expressive or receptive language may be a risk marker for ASD in a high-risk sample. |
| first_indexed | 2024-03-08T07:10:43Z |
| format | Article |
| id | doaj.art-7d06cde99597488daa6706b4d2294ecb |
| institution | Directory Open Access Journal |
| issn | 2396-9415 |
| language | English |
| last_indexed | 2024-03-08T07:10:43Z |
| publishDate | 2017-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Autism and Developmental Language Impairments |
| spelling | doaj.art-7d06cde99597488daa6706b4d2294ecb2024-02-03T02:51:38ZengSAGE PublishingAutism and Developmental Language Impairments2396-94152017-11-01210.1177/2396941517737418Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorderJulie LongardJessica BrianLonnie ZwaigenbaumEric DukuChris MooreIsabel M SmithNancy GaronPeter SzatmariTracy VaillancourtSusan BrysonBackground & aims In response to limited research on early language development in infants at high risk for Autism Spectrum Disorder (ASD), the current prospective study examined early expressive and receptive language trajectories in familial high-risk (HR) infants who were and were not later diagnosed with ASD (HR-ASD and HR-N, respectively), and low-risk (LR) controls with no family history of ASD. Methods Participants were 523 children (371 HR siblings, 56% boys; 152 LR controls, 52% boys) followed from age 6 or 12 months to 36 months. Based on independent, best-estimate clinical diagnoses at 36 months, HR participants were classified as HR-ASD (n = 94; 69% boys), or HR-N (n = 277; 52% boys); the sample also included 152 LR controls (52% boys). Expressive and receptive language trajectories were examined based on corresponding domain standard scores on the Mullen Scales of Early Learning ( MSEL ) at 6, 12, 24, and 36 months. In the combined sample of HR and LR infants, semi-parametric group-based modeling was used to identify distinct trajectories in MSEL standard scores. Results A 3-group solution provided optimal fit to variation in both expressive and receptive language, with the following patterns of scores: (1) inclining from average to above average, (2) stable-average, and (3) declining from average to well below average. For both expressive and receptive language, membership in these trajectories was related to 3-year diagnostic outcomes. Conclusions Although HR-ASD, HR-N, and LR control infants were in each trajectory group, membership in the declining trajectory (expressive and/or receptive) was associated with an ASD diagnosis. Implications Evidence of declining trajectories in either expressive or receptive language may be a risk marker for ASD in a high-risk sample.https://doi.org/10.1177/2396941517737418 |
| spellingShingle | Julie Longard Jessica Brian Lonnie Zwaigenbaum Eric Duku Chris Moore Isabel M Smith Nancy Garon Peter Szatmari Tracy Vaillancourt Susan Bryson Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder Autism and Developmental Language Impairments |
| title | Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder |
| title_full | Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder |
| title_fullStr | Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder |
| title_full_unstemmed | Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder |
| title_short | Early expressive and receptive language trajectories in high-risk infant siblings of children with autism spectrum disorder |
| title_sort | early expressive and receptive language trajectories in high risk infant siblings of children with autism spectrum disorder |
| url | https://doi.org/10.1177/2396941517737418 |
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