Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review

Lipotoxic Impairment of Mitochondrial Function in β-Cells: A Review

Lipotoxicity is a major contributor to type 2 diabetes mainly promoting mitochondrial dysfunction. Lipotoxic stress is mediated by elevated levels of free fatty acids through various mechanisms and pathways. Impaired peroxisome proliferator-activated receptor (PPAR) signaling, enhanced oxidative str...

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Bibliographic Details
Main Authors:	Axel Römer, Thomas Linn, Sebastian F. Petry
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Antioxidants
Subjects:	lipotoxicity free fatty acids oxidative stress mitochondrial dysfunction beta cell diabetes mellitus
Online Access:	https://www.mdpi.com/2076-3921/10/2/293

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