Pod-based e-cigarettes versus combustible cigarettes: The impact on peripheral and cerebral vascular function and subjective experiences
Introduction The vaping epidemic in the US has been largely attributed to the emergence of pod-based e-cigarette devices. While these devices continue to be promoted as alternatives to cigarettes, their impact on cardiovascular and behavioral outcomes remains incompletely understood. This study asse...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Publishing
2023-05-01
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| Series: | Tobacco Induced Diseases |
| Subjects: | |
| Online Access: | http://www.tobaccoinduceddiseases.org/Pod-based-e-cigarettes-versus-combustible-cigarettes-The-nimpact-on-peripheral-and,162366,0,2.html |
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| author | Ziyad Ben Taleb Danny Dabroy John Akins Michael Douglas Nelson Mohammed Ebrahimi Kalan Mary Rezk-Hanna R. Matthew Brothers |
| author_facet | Ziyad Ben Taleb Danny Dabroy John Akins Michael Douglas Nelson Mohammed Ebrahimi Kalan Mary Rezk-Hanna R. Matthew Brothers |
| author_sort | Ziyad Ben Taleb |
| collection | DOAJ |
| description | Introduction
The vaping epidemic in the US has been largely attributed to the
emergence of pod-based e-cigarette devices. While these devices continue to
be promoted as alternatives to cigarettes, their impact on cardiovascular and
behavioral outcomes remains incompletely understood. This study assessed the
impact of pod-based e-cigarettes on peripheral and cerebral vascular function,
along with subjective experiences among adult cigarette smokers.
Methods
In a crossover laboratory design study, a total of 19 (e-cigarette naïve)
cigarette smokers (aged 21–43 years) attended two lab sessions. In one session,
participants smoked a cigarette and in the other, vaped a pod-based e-cigarette.
Participants completed questions assessing subjective experiences. Peripheral
macrovascular and microvascular function was assessed via brachial artery FMD
and reactive hyperemia, while cerebral vascular function was assessed as the blood
velocity response of the middle cerebral artery during hypercapnia. Measurements
were taken before and after exposure.
Results
Compared with baseline, there was a reduction in peripheral macrovascular
function (indexed by FMD), following e-cigarette (pre=9.3±4.3%; post=6.4±4.1%)
and cigarette use (pre=10.2±3.7%; post=6.8±3.8%; main effect of time p<0.0001).
Cerebral vascular function (indexed by cerebral vasodilatory response during
hypercapnia) was also reduced following e-cigarette (pre=53±19%; post=44±15%)
and cigarette use (pre=54±21%; post=44±17%; main effect of time p 0.05). Compared with vaping
an e-cigarette, participants scored higher for measures of satisfaction, taste, puff
liking, and suppression of craving following smoking (p>0.05).
Conclusions
Similar to smoking, vaping a pod-based e-cigarette leads to an
impairment in peripheral and cerebral vascular function while providing a reduced
subjective experience compared with a cigarette among adult smokers. While
these data challenge the notion that e-cigarette use is a safe and satisfactory
alternative to cigarette use, large longitudinal studies are needed to assess
the long-term impact of pod-based e-cigarette devices on cardiovascular and
behavioral outcomes. |
| first_indexed | 2024-03-13T01:04:55Z |
| format | Article |
| id | doaj.art-7d08ace7a4ff4858801163fa7ee3b0e0 |
| institution | Directory Open Access Journal |
| issn | 1617-9625 |
| language | English |
| last_indexed | 2024-03-13T01:04:55Z |
| publishDate | 2023-05-01 |
| publisher | European Publishing |
| record_format | Article |
| series | Tobacco Induced Diseases |
| spelling | doaj.art-7d08ace7a4ff4858801163fa7ee3b0e02023-07-06T07:46:44ZengEuropean PublishingTobacco Induced Diseases1617-96252023-05-0121May11110.18332/tid/162366162366Pod-based e-cigarettes versus combustible cigarettes: The impact on peripheral and cerebral vascular function and subjective experiencesZiyad Ben Taleb0https://orcid.org/0000-0001-6894-5535Danny Dabroy1John Akins2Michael Douglas Nelson3https://orcid.org/0000-0002-3232-8639Mohammed Ebrahimi Kalan4https://orcid.org/0000-0001-7709-5392Mary Rezk-Hanna5R. Matthew Brothers6https://orcid.org/0000-0002-3281-5277Department of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, United StatesDepartment of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, United StatesDepartment of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, United StatesDepartment of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, United StatesSchool of Health Professions, Eastern Virginia Medical School, Norfolk, United StatesSchool of Nursing, University of California, Los Angeles, Los Angeles, United StatesDepartment of Kinesiology, College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, United StatesIntroduction The vaping epidemic in the US has been largely attributed to the emergence of pod-based e-cigarette devices. While these devices continue to be promoted as alternatives to cigarettes, their impact on cardiovascular and behavioral outcomes remains incompletely understood. This study assessed the impact of pod-based e-cigarettes on peripheral and cerebral vascular function, along with subjective experiences among adult cigarette smokers. Methods In a crossover laboratory design study, a total of 19 (e-cigarette naïve) cigarette smokers (aged 21–43 years) attended two lab sessions. In one session, participants smoked a cigarette and in the other, vaped a pod-based e-cigarette. Participants completed questions assessing subjective experiences. Peripheral macrovascular and microvascular function was assessed via brachial artery FMD and reactive hyperemia, while cerebral vascular function was assessed as the blood velocity response of the middle cerebral artery during hypercapnia. Measurements were taken before and after exposure. Results Compared with baseline, there was a reduction in peripheral macrovascular function (indexed by FMD), following e-cigarette (pre=9.3±4.3%; post=6.4±4.1%) and cigarette use (pre=10.2±3.7%; post=6.8±3.8%; main effect of time p<0.0001). Cerebral vascular function (indexed by cerebral vasodilatory response during hypercapnia) was also reduced following e-cigarette (pre=53±19%; post=44±15%) and cigarette use (pre=54±21%; post=44±17%; main effect of time p 0.05). Compared with vaping an e-cigarette, participants scored higher for measures of satisfaction, taste, puff liking, and suppression of craving following smoking (p>0.05). Conclusions Similar to smoking, vaping a pod-based e-cigarette leads to an impairment in peripheral and cerebral vascular function while providing a reduced subjective experience compared with a cigarette among adult smokers. While these data challenge the notion that e-cigarette use is a safe and satisfactory alternative to cigarette use, large longitudinal studies are needed to assess the long-term impact of pod-based e-cigarette devices on cardiovascular and behavioral outcomes.http://www.tobaccoinduceddiseases.org/Pod-based-e-cigarettes-versus-combustible-cigarettes-The-nimpact-on-peripheral-and,162366,0,2.htmlpod-based e-cigarettecigarettesvapingsmokingcardiovascular disease risk |
| spellingShingle | Ziyad Ben Taleb Danny Dabroy John Akins Michael Douglas Nelson Mohammed Ebrahimi Kalan Mary Rezk-Hanna R. Matthew Brothers Pod-based e-cigarettes versus combustible cigarettes: The impact on peripheral and cerebral vascular function and subjective experiences Tobacco Induced Diseases pod-based e-cigarette cigarettes vaping smoking cardiovascular disease risk |
| title | Pod-based e-cigarettes versus combustible cigarettes: The
impact on peripheral and cerebral vascular function and
subjective experiences |
| title_full | Pod-based e-cigarettes versus combustible cigarettes: The
impact on peripheral and cerebral vascular function and
subjective experiences |
| title_fullStr | Pod-based e-cigarettes versus combustible cigarettes: The
impact on peripheral and cerebral vascular function and
subjective experiences |
| title_full_unstemmed | Pod-based e-cigarettes versus combustible cigarettes: The
impact on peripheral and cerebral vascular function and
subjective experiences |
| title_short | Pod-based e-cigarettes versus combustible cigarettes: The
impact on peripheral and cerebral vascular function and
subjective experiences |
| title_sort | pod based e cigarettes versus combustible cigarettes the impact on peripheral and cerebral vascular function and subjective experiences |
| topic | pod-based e-cigarette cigarettes vaping smoking cardiovascular disease risk |
| url | http://www.tobaccoinduceddiseases.org/Pod-based-e-cigarettes-versus-combustible-cigarettes-The-nimpact-on-peripheral-and,162366,0,2.html |
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