STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE
ABSTRACT Alzheimer’s is a neurodegenerative disease characterized by cognitive impairment commonly associated with mood disorders, which trigger depressive reactions and compromise mental performance and functionality. The objective of the present study was to verify the effects of L-tryptophan and...
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| Format: | Article |
| Language: | English |
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Universidade Estadual de Maringá
2017-10-01
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| Series: | Journal of Physical Education |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2448-24552017000100139&tlng=en |
| _version_ | 1798020748738035712 |
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| author | Andressa Leticia Miri Andressa Panegalli Hosni Jossinelma Camargo Gomes Ivo Ilvan Kerppers Mário César da Silva Pereira |
| author_facet | Andressa Leticia Miri Andressa Panegalli Hosni Jossinelma Camargo Gomes Ivo Ilvan Kerppers Mário César da Silva Pereira |
| author_sort | Andressa Leticia Miri |
| collection | DOAJ |
| description | ABSTRACT Alzheimer’s is a neurodegenerative disease characterized by cognitive impairment commonly associated with mood disorders, which trigger depressive reactions and compromise mental performance and functionality. The objective of the present study was to verify the effects of L-tryptophan and to analyze motor behavior in an experimental model of depression caused by the Alzheimer’s disease process. The sample consisted of 40 Wistar rats divided equally into two groups, 20 animals treated with L-tryptophan and 20 control animals. Both groups received spatial memory training in the water maze task and were submitted to stereotaxic surgery to induce dementia. The treated group achieved better spatial memory activity than the control group in the Morris water maze. Treatment with L-tryptophan had beneficial effects on reactive memory. |
| first_indexed | 2024-04-11T17:02:41Z |
| format | Article |
| id | doaj.art-7d08bbaebd2e4215b08acea029f3fdbd |
| institution | Directory Open Access Journal |
| issn | 2448-2455 |
| language | English |
| last_indexed | 2024-04-11T17:02:41Z |
| publishDate | 2017-10-01 |
| publisher | Universidade Estadual de Maringá |
| record_format | Article |
| series | Journal of Physical Education |
| spelling | doaj.art-7d08bbaebd2e4215b08acea029f3fdbd2022-12-22T04:13:07ZengUniversidade Estadual de MaringáJournal of Physical Education2448-24552017-10-012810.4025/jphyseduc.v28i1.2839STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASEAndressa Leticia MiriAndressa Panegalli HosniJossinelma Camargo GomesIvo Ilvan KerppersMário César da Silva PereiraABSTRACT Alzheimer’s is a neurodegenerative disease characterized by cognitive impairment commonly associated with mood disorders, which trigger depressive reactions and compromise mental performance and functionality. The objective of the present study was to verify the effects of L-tryptophan and to analyze motor behavior in an experimental model of depression caused by the Alzheimer’s disease process. The sample consisted of 40 Wistar rats divided equally into two groups, 20 animals treated with L-tryptophan and 20 control animals. Both groups received spatial memory training in the water maze task and were submitted to stereotaxic surgery to induce dementia. The treated group achieved better spatial memory activity than the control group in the Morris water maze. Treatment with L-tryptophan had beneficial effects on reactive memory.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2448-24552017000100139&tlng=enAlzheimer’s DiseaseDepressionSerotoninTryptophan. |
| spellingShingle | Andressa Leticia Miri Andressa Panegalli Hosni Jossinelma Camargo Gomes Ivo Ilvan Kerppers Mário César da Silva Pereira STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE Journal of Physical Education Alzheimer’s Disease Depression Serotonin Tryptophan. |
| title | STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE |
| title_full | STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE |
| title_fullStr | STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE |
| title_full_unstemmed | STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE |
| title_short | STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE |
| title_sort | study of l tryptophan in an experimental model of depression caused by alzheimer s disease |
| topic | Alzheimer’s Disease Depression Serotonin Tryptophan. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2448-24552017000100139&tlng=en |
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