Evidence of Inbreeding in Hodgkin Lymphoma.
Genome-wide association studies (GWASs) have identified several, mainly co-dominantly acting, single-nucleotide polymorphisms (SNPs) associated with Hodgkin lymphoma (HL). We searched for recessively acting disease loci by performing an analysis of runs of homozygosity (ROH) based on windows of homo...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4849743?pdf=render |
| _version_ | 1818517722605027328 |
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| author | Hauke Thomsen Miguel Inacio da Silva Filho Michael Fuchs Sabine Ponader Elke Pogge von Strandmann Lewin Eisele Stefan Herms Per Hoffmann Andreas Engert Kari Hemminki Asta Försti |
| author_facet | Hauke Thomsen Miguel Inacio da Silva Filho Michael Fuchs Sabine Ponader Elke Pogge von Strandmann Lewin Eisele Stefan Herms Per Hoffmann Andreas Engert Kari Hemminki Asta Försti |
| author_sort | Hauke Thomsen |
| collection | DOAJ |
| description | Genome-wide association studies (GWASs) have identified several, mainly co-dominantly acting, single-nucleotide polymorphisms (SNPs) associated with Hodgkin lymphoma (HL). We searched for recessively acting disease loci by performing an analysis of runs of homozygosity (ROH) based on windows of homozygous SNP-blocks and by calculating genomic inbreeding coefficients on a SNP-wise basis. We used data from a previous GWAS with 906 cases and 1217 controls from a population with a long history of no matings between relatives. Ten recurrent ROHs were identified among 25 055 ROHs across all individuals but their association with HL was not genome-wide significant. All recurrent ROHs showed significant evidence for natural selection. As a novel finding genomic inbreeding among cases was significantly higher than among controls (P = 2.11*10-14) even after correcting for covariates. Higher inbreeding among the cases was mainly based on a group of individuals with a higher average length of ROHs per person. This result suggests a correlation of higher levels of inbreeding with higher cancer incidence and might reflect the existence of recessive alleles causing HL. Genomic inbreeding may result in a higher expression of deleterious recessive genes within a population. |
| first_indexed | 2024-12-11T01:00:08Z |
| format | Article |
| id | doaj.art-7d0c838081be4c649cc1c01b6e6c61ea |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T01:00:08Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7d0c838081be4c649cc1c01b6e6c61ea2022-12-22T01:26:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015425910.1371/journal.pone.0154259Evidence of Inbreeding in Hodgkin Lymphoma.Hauke ThomsenMiguel Inacio da Silva FilhoMichael FuchsSabine PonaderElke Pogge von StrandmannLewin EiseleStefan HermsPer HoffmannAndreas EngertKari HemminkiAsta FörstiGenome-wide association studies (GWASs) have identified several, mainly co-dominantly acting, single-nucleotide polymorphisms (SNPs) associated with Hodgkin lymphoma (HL). We searched for recessively acting disease loci by performing an analysis of runs of homozygosity (ROH) based on windows of homozygous SNP-blocks and by calculating genomic inbreeding coefficients on a SNP-wise basis. We used data from a previous GWAS with 906 cases and 1217 controls from a population with a long history of no matings between relatives. Ten recurrent ROHs were identified among 25 055 ROHs across all individuals but their association with HL was not genome-wide significant. All recurrent ROHs showed significant evidence for natural selection. As a novel finding genomic inbreeding among cases was significantly higher than among controls (P = 2.11*10-14) even after correcting for covariates. Higher inbreeding among the cases was mainly based on a group of individuals with a higher average length of ROHs per person. This result suggests a correlation of higher levels of inbreeding with higher cancer incidence and might reflect the existence of recessive alleles causing HL. Genomic inbreeding may result in a higher expression of deleterious recessive genes within a population.http://europepmc.org/articles/PMC4849743?pdf=render |
| spellingShingle | Hauke Thomsen Miguel Inacio da Silva Filho Michael Fuchs Sabine Ponader Elke Pogge von Strandmann Lewin Eisele Stefan Herms Per Hoffmann Andreas Engert Kari Hemminki Asta Försti Evidence of Inbreeding in Hodgkin Lymphoma. PLoS ONE |
| title | Evidence of Inbreeding in Hodgkin Lymphoma. |
| title_full | Evidence of Inbreeding in Hodgkin Lymphoma. |
| title_fullStr | Evidence of Inbreeding in Hodgkin Lymphoma. |
| title_full_unstemmed | Evidence of Inbreeding in Hodgkin Lymphoma. |
| title_short | Evidence of Inbreeding in Hodgkin Lymphoma. |
| title_sort | evidence of inbreeding in hodgkin lymphoma |
| url | http://europepmc.org/articles/PMC4849743?pdf=render |
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