The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a physiological process that begins in utero and continues throughout life in both good health and disease. Understanding the underlying mechanism in angiogenesis could uncover a new therapeutic approach in pathologic...
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| Format: | Article |
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MDPI AG
2019-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/5/407 |
| _version_ | 1797713628742287360 |
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| author | Taha Azad Mina Ghahremani Xiaolong Yang |
| author_facet | Taha Azad Mina Ghahremani Xiaolong Yang |
| author_sort | Taha Azad |
| collection | DOAJ |
| description | Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a physiological process that begins in utero and continues throughout life in both good health and disease. Understanding the underlying mechanism in angiogenesis could uncover a new therapeutic approach in pathological angiogenesis. Since its discovery, the Hippo signaling pathway has emerged as a key player in controlling organ size and tissue homeostasis. Recently, new studies have discovered that Hippo and two of its main effectors, Yes-associated protein (YAP) and its paralog transcription activator with PDZ binding motif (TAZ), play critical roles during angiogenesis. In this review, we summarize the mechanisms by which YAP/TAZ regulate endothelial cell shape, behavior, and function in angiogenesis. We further discuss how YAP/TAZ function as part of developmental and pathological angiogenesis. Finally, we review the role of YAP/TAZ in tumor vascular mimicry and propose directions for future work. |
| first_indexed | 2024-03-12T07:39:31Z |
| format | Article |
| id | doaj.art-7d0c9cb4e3dc4a9a95d2f2b28c3a1cee |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:39:31Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7d0c9cb4e3dc4a9a95d2f2b28c3a1cee2023-09-02T21:22:20ZengMDPI AGCells2073-44092019-05-018540710.3390/cells8050407cells8050407The Role of YAP and TAZ in Angiogenesis and Vascular MimicryTaha Azad0Mina Ghahremani1Xiaolong Yang2Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Biology, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, CanadaAngiogenesis, the formation of new blood vessels from pre-existing vasculature, is a physiological process that begins in utero and continues throughout life in both good health and disease. Understanding the underlying mechanism in angiogenesis could uncover a new therapeutic approach in pathological angiogenesis. Since its discovery, the Hippo signaling pathway has emerged as a key player in controlling organ size and tissue homeostasis. Recently, new studies have discovered that Hippo and two of its main effectors, Yes-associated protein (YAP) and its paralog transcription activator with PDZ binding motif (TAZ), play critical roles during angiogenesis. In this review, we summarize the mechanisms by which YAP/TAZ regulate endothelial cell shape, behavior, and function in angiogenesis. We further discuss how YAP/TAZ function as part of developmental and pathological angiogenesis. Finally, we review the role of YAP/TAZ in tumor vascular mimicry and propose directions for future work.https://www.mdpi.com/2073-4409/8/5/407Hippo pathwaycancerangiogenesisvascular mimicryYAPTAZMST1/2LATS1/2 |
| spellingShingle | Taha Azad Mina Ghahremani Xiaolong Yang The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry Cells Hippo pathway cancer angiogenesis vascular mimicry YAP TAZ MST1/2 LATS1/2 |
| title | The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry |
| title_full | The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry |
| title_fullStr | The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry |
| title_full_unstemmed | The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry |
| title_short | The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry |
| title_sort | role of yap and taz in angiogenesis and vascular mimicry |
| topic | Hippo pathway cancer angiogenesis vascular mimicry YAP TAZ MST1/2 LATS1/2 |
| url | https://www.mdpi.com/2073-4409/8/5/407 |
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