On Naevi and Melanomas: Two Sides of the Same Coin?
Benign naevi are closely linked to melanoma, as risk factors, simulators, or sites of melanoma formation. There is a heavy genetic overlap between the two lesions, a shared environmental influence of ultraviolet radiation, and many similar cellular features, yet naevi remain locally situated while m...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.635316/full |
| _version_ | 1818446070348251136 |
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| author | Katie J. Lee Monika Janda Mitchell S. Stark Richard A. Sturm H. Peter Soyer H. Peter Soyer |
| author_facet | Katie J. Lee Monika Janda Mitchell S. Stark Richard A. Sturm H. Peter Soyer H. Peter Soyer |
| author_sort | Katie J. Lee |
| collection | DOAJ |
| description | Benign naevi are closely linked to melanoma, as risk factors, simulators, or sites of melanoma formation. There is a heavy genetic overlap between the two lesions, a shared environmental influence of ultraviolet radiation, and many similar cellular features, yet naevi remain locally situated while melanomas spread from their primary site and may progress systemically to distal organs. Untangling the overlapping contributors and predictors of naevi and melanoma is an ongoing area of research and should eventually lead to more personalized prevention and treatment strategies, through the development of melanoma risk stratification tools and early detection of evolving melanomas. This will be achieved through a range of complementary strategies: risk-adjusted primary prevention counseling; the use of lesion imaging technologies such as sequential 3D total body photography and consumer-performed lesion imaging; artificial intelligence deep phenotyping and clinical assistance; a better understanding of genetic drivers of malignancy, risk variants, clinical genetics, and polygenic effects; and the interplay between genetics, phenotype and the environment. |
| first_indexed | 2024-12-14T19:41:53Z |
| format | Article |
| id | doaj.art-7d0f0ad2cc00469392b605acac8c76ac |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-14T19:41:53Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-7d0f0ad2cc00469392b605acac8c76ac2022-12-21T22:49:42ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-02-01810.3389/fmed.2021.635316635316On Naevi and Melanomas: Two Sides of the Same Coin?Katie J. Lee0Monika Janda1Mitchell S. Stark2Richard A. Sturm3H. Peter Soyer4H. Peter Soyer5Dermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, AustraliaCentre for Health Services Research, The University of Queensland, Brisbane, QLD, AustraliaDermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, AustraliaDermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, AustraliaDermatology Research Centre, The University of Queensland Diamantina Institute, The University of Queensland, Brisbane, QLD, AustraliaDepartment of Dermatology, Princess Alexandra Hospital, Brisbane, QLD, AustraliaBenign naevi are closely linked to melanoma, as risk factors, simulators, or sites of melanoma formation. There is a heavy genetic overlap between the two lesions, a shared environmental influence of ultraviolet radiation, and many similar cellular features, yet naevi remain locally situated while melanomas spread from their primary site and may progress systemically to distal organs. Untangling the overlapping contributors and predictors of naevi and melanoma is an ongoing area of research and should eventually lead to more personalized prevention and treatment strategies, through the development of melanoma risk stratification tools and early detection of evolving melanomas. This will be achieved through a range of complementary strategies: risk-adjusted primary prevention counseling; the use of lesion imaging technologies such as sequential 3D total body photography and consumer-performed lesion imaging; artificial intelligence deep phenotyping and clinical assistance; a better understanding of genetic drivers of malignancy, risk variants, clinical genetics, and polygenic effects; and the interplay between genetics, phenotype and the environment.https://www.frontiersin.org/articles/10.3389/fmed.2021.635316/fullprecancerprecursor lesiongenetics and genomicsartificial intelligencerisk stratificationmelanoma |
| spellingShingle | Katie J. Lee Monika Janda Mitchell S. Stark Richard A. Sturm H. Peter Soyer H. Peter Soyer On Naevi and Melanomas: Two Sides of the Same Coin? Frontiers in Medicine precancer precursor lesion genetics and genomics artificial intelligence risk stratification melanoma |
| title | On Naevi and Melanomas: Two Sides of the Same Coin? |
| title_full | On Naevi and Melanomas: Two Sides of the Same Coin? |
| title_fullStr | On Naevi and Melanomas: Two Sides of the Same Coin? |
| title_full_unstemmed | On Naevi and Melanomas: Two Sides of the Same Coin? |
| title_short | On Naevi and Melanomas: Two Sides of the Same Coin? |
| title_sort | on naevi and melanomas two sides of the same coin |
| topic | precancer precursor lesion genetics and genomics artificial intelligence risk stratification melanoma |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.635316/full |
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