eIF4E as a Control Target for Viruses
Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various stu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-02-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/7/2/739 |
| _version_ | 1818175709802135552 |
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| author | Hilda Montero Rebeca García-Román Silvia I. Mora |
| author_facet | Hilda Montero Rebeca García-Román Silvia I. Mora |
| author_sort | Hilda Montero |
| collection | DOAJ |
| description | Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves. |
| first_indexed | 2024-12-11T20:04:37Z |
| format | Article |
| id | doaj.art-7d0f913e29374d3390ea79fa3217de2c |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-11T20:04:37Z |
| publishDate | 2015-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-7d0f913e29374d3390ea79fa3217de2c2022-12-22T00:52:26ZengMDPI AGViruses1999-49152015-02-017273975010.3390/v7020739v7020739eIF4E as a Control Target for VirusesHilda Montero0Rebeca García-Román1Silvia I. Mora2Public Health Institute, University of Veracruz, Veracruz 91190, MexicoPublic Health Institute, University of Veracruz, Veracruz 91190, MexicoPreparative Procedures and Access to Proteomic Services Unit, Institute of Biomedical Research, National Autonomous University of Mexico. Distrito Federal 04510, MexicoTranslation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves.http://www.mdpi.com/1999-4915/7/2/739eIF4E4EBPvirustranslationlatencycancer |
| spellingShingle | Hilda Montero Rebeca García-Román Silvia I. Mora eIF4E as a Control Target for Viruses Viruses eIF4E 4EBP virus translation latency cancer |
| title | eIF4E as a Control Target for Viruses |
| title_full | eIF4E as a Control Target for Viruses |
| title_fullStr | eIF4E as a Control Target for Viruses |
| title_full_unstemmed | eIF4E as a Control Target for Viruses |
| title_short | eIF4E as a Control Target for Viruses |
| title_sort | eif4e as a control target for viruses |
| topic | eIF4E 4EBP virus translation latency cancer |
| url | http://www.mdpi.com/1999-4915/7/2/739 |
| work_keys_str_mv | AT hildamontero eif4easacontroltargetforviruses AT rebecagarciaroman eif4easacontroltargetforviruses AT silviaimora eif4easacontroltargetforviruses |