Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids

Activation and Desensitization of Peripheral Muscle and Neuronal Nicotinic Acetylcholine Receptors by Selected, Naturally-Occurring Pyridine Alkaloids

Teratogenic alkaloids can cause developmental defects due to the inhibition of fetal movement that results from desensitization of fetal muscle-type nicotinic acetylcholine receptors (nAChRs). We investigated the ability of two known teratogens, the piperidinyl-pyridine anabasine and its 1,2-dehydro...

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Bibliographic Details
Main Authors: Benedict T. Green, Stephen T. Lee, Kevin D. Welch, Daniel Cook, William R. Kem
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Toxins
Subjects:
anabaseine
anabasine
epibatidine
nicotinic acetylcholine receptor
nicotine
pyridine alkaloid
Online Access:http://www.mdpi.com/2072-6651/8/7/204

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