The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP
RNA chaperone protein Hfq is an important post-transcriptional regulator in bacteria, while c-di-GMP is a second messenger signaling molecule widely distributed in bacteria. Both factors have been found to play key roles in post-transcriptional regulation and signal transduction pathways, respective...
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| Format: | Article |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.689619/full |
| _version_ | 1818668689736597504 |
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| author | Yang Fu Yang Fu Zhaoqing Yu Li Zhu Zhou Li Wen Yin Xiaodong Shang Shan-Ho Chou Qi Tan Jin He |
| author_facet | Yang Fu Yang Fu Zhaoqing Yu Li Zhu Zhou Li Wen Yin Xiaodong Shang Shan-Ho Chou Qi Tan Jin He |
| author_sort | Yang Fu |
| collection | DOAJ |
| description | RNA chaperone protein Hfq is an important post-transcriptional regulator in bacteria, while c-di-GMP is a second messenger signaling molecule widely distributed in bacteria. Both factors have been found to play key roles in post-transcriptional regulation and signal transduction pathways, respectively. Intriguingly, the two factors show some common aspects in the regulation of certain physiological functions such as bacterial motility, biofilm formation, pathogenicity and so on. Therefore, there may be regulatory relationship between Hfq and c-di-GMP. For example, Hfq can directly regulate the activity of c-di-GMP metabolic enzymes or alter the c-di-GMP level through other systems, while c-di-GMP can indirectly enhance or inhibit the hfq gene expression through intermediate factors. In this article, after briefly introducing the Hfq and c-di-GMP regulatory systems, we will focus on the direct and indirect regulation reported between Hfq and c-di-GMP, aiming to compare and link the two regulatory systems to further study the complicated physiological and metabolic systems of bacteria, and to lay a solid foundation for drawing a more complete global regulatory network. |
| first_indexed | 2024-12-17T06:40:19Z |
| format | Article |
| id | doaj.art-7d14a4ee87b04659987061fbf87d64b7 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-17T06:40:19Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7d14a4ee87b04659987061fbf87d64b72022-12-21T21:59:52ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-07-011210.3389/fmicb.2021.689619689619The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMPYang Fu0Yang Fu1Zhaoqing Yu2Li Zhu3Zhou Li4Wen Yin5Xiaodong Shang6Shan-Ho Chou7Qi Tan8Jin He9National Engineering Research Center of Edible Fungi, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaNational Engineering Research Center of Edible Fungi, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaNational Engineering Research Center of Edible Fungi, Institute of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai, ChinaState Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, ChinaRNA chaperone protein Hfq is an important post-transcriptional regulator in bacteria, while c-di-GMP is a second messenger signaling molecule widely distributed in bacteria. Both factors have been found to play key roles in post-transcriptional regulation and signal transduction pathways, respectively. Intriguingly, the two factors show some common aspects in the regulation of certain physiological functions such as bacterial motility, biofilm formation, pathogenicity and so on. Therefore, there may be regulatory relationship between Hfq and c-di-GMP. For example, Hfq can directly regulate the activity of c-di-GMP metabolic enzymes or alter the c-di-GMP level through other systems, while c-di-GMP can indirectly enhance or inhibit the hfq gene expression through intermediate factors. In this article, after briefly introducing the Hfq and c-di-GMP regulatory systems, we will focus on the direct and indirect regulation reported between Hfq and c-di-GMP, aiming to compare and link the two regulatory systems to further study the complicated physiological and metabolic systems of bacteria, and to lay a solid foundation for drawing a more complete global regulatory network.https://www.frontiersin.org/articles/10.3389/fmicb.2021.689619/fullRNA-chaperone Hfqc-di-GMPsmall RNAc-di-GMP metabolic enzymesbiofilmmotility |
| spellingShingle | Yang Fu Yang Fu Zhaoqing Yu Li Zhu Zhou Li Wen Yin Xiaodong Shang Shan-Ho Chou Qi Tan Jin He The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP Frontiers in Microbiology RNA-chaperone Hfq c-di-GMP small RNA c-di-GMP metabolic enzymes biofilm motility |
| title | The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP |
| title_full | The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP |
| title_fullStr | The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP |
| title_full_unstemmed | The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP |
| title_short | The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP |
| title_sort | multiple regulatory relationship between rna chaperone hfq and the second messenger c di gmp |
| topic | RNA-chaperone Hfq c-di-GMP small RNA c-di-GMP metabolic enzymes biofilm motility |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.689619/full |
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