Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment
BackgroundMaking advantageous decisions is essential in everyday life. Our objective was to assess how patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) make decisions under conditions of ambiguity or risk. In addition, the study also aimed to examine the relationship betwee...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00218/full |
| _version_ | 1819112334676721664 |
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| author | Tingting Sun Tingting Sun Teng Xie Teng Xie Jing Wang Jing Wang Long Zhang Yanghua Tian Kai Wang Xin Yu Xin Yu Huali Wang Huali Wang |
| author_facet | Tingting Sun Tingting Sun Teng Xie Teng Xie Jing Wang Jing Wang Long Zhang Yanghua Tian Kai Wang Xin Yu Xin Yu Huali Wang Huali Wang |
| author_sort | Tingting Sun |
| collection | DOAJ |
| description | BackgroundMaking advantageous decisions is essential in everyday life. Our objective was to assess how patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) make decisions under conditions of ambiguity or risk. In addition, the study also aimed to examine the relationship between decision-making competence and memory and executive function.MethodsPatients with MCI (n = 36) and AD (n = 29) and healthy elderly controls (HC, n = 34) were recruited from the memory clinic. All subjects were administered a comprehensive neuropsychological battery test. We used the Iowa Gambling Task (IGT) to measure decision-making under ambiguity and the Game of Dice Task (GDT) to measure decision-making under risk. Pearson’s correlation was used to examine the relationship between the performance of IGT and GDT with delayed recall and the Stroop test.ResultsIn the GDT, MCI and AD patients presented similar performance but showed different patterns when compared with the HC group. The proportion of those making advantageous choices was lower in the AD group than in the HC group (p = 0.01), while the MCI and HC groups did not differ (p = 0.14). Meanwhile, concerning the ratio of accepting negative feedback, the AD (p < 0.01) group was significantly different from the HC patients, but the MCI (p = 0.06) and HC groups did not differ. In the IGT, MCI and AD patients selected randomly from advantageous and disadvantageous decks (p = 0.94 and p = 0.54), showing no significant change in performance over time. In contrast, the HC group made increasingly frequent advantageous selections over time (p = 0.04). Furthermore, the proportion of advantageous decision-makers for the GDT had a linear relationship with delayed recall of the Hopkins Verbal Learning Test and Stroop color words (p < 0.01 and p < 0.01, respectively).ConclusionOur findings suggest that decision-making ability under ambiguity is compromised in MCI and AD, and the decision-making under risk is only impaired in AD. Reduced decision-making performance under risk is closely correlated with lower executive functions and memory. |
| first_indexed | 2024-12-22T04:11:52Z |
| format | Article |
| id | doaj.art-7d169fcad35640ba98d4ad26c68d231b |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T04:11:52Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-7d169fcad35640ba98d4ad26c68d231b2022-12-21T18:39:30ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-03-011110.3389/fpsyt.2020.00218470139Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive ImpairmentTingting Sun0Tingting Sun1Teng Xie2Teng Xie3Jing Wang4Jing Wang5Long Zhang6Yanghua Tian7Kai Wang8Xin Yu9Xin Yu10Huali Wang11Huali Wang12Dementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing Dementia Key Lab, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, ChinaDementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing Dementia Key Lab, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, ChinaDementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing Dementia Key Lab, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, ChinaDementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing Dementia Key Lab, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, ChinaDementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing Dementia Key Lab, Beijing, ChinaNational Clinical Research Center for Mental Disorders, Key Laboratory for Mental Health, National Health Commission, Beijing, ChinaBackgroundMaking advantageous decisions is essential in everyday life. Our objective was to assess how patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD) make decisions under conditions of ambiguity or risk. In addition, the study also aimed to examine the relationship between decision-making competence and memory and executive function.MethodsPatients with MCI (n = 36) and AD (n = 29) and healthy elderly controls (HC, n = 34) were recruited from the memory clinic. All subjects were administered a comprehensive neuropsychological battery test. We used the Iowa Gambling Task (IGT) to measure decision-making under ambiguity and the Game of Dice Task (GDT) to measure decision-making under risk. Pearson’s correlation was used to examine the relationship between the performance of IGT and GDT with delayed recall and the Stroop test.ResultsIn the GDT, MCI and AD patients presented similar performance but showed different patterns when compared with the HC group. The proportion of those making advantageous choices was lower in the AD group than in the HC group (p = 0.01), while the MCI and HC groups did not differ (p = 0.14). Meanwhile, concerning the ratio of accepting negative feedback, the AD (p < 0.01) group was significantly different from the HC patients, but the MCI (p = 0.06) and HC groups did not differ. In the IGT, MCI and AD patients selected randomly from advantageous and disadvantageous decks (p = 0.94 and p = 0.54), showing no significant change in performance over time. In contrast, the HC group made increasingly frequent advantageous selections over time (p = 0.04). Furthermore, the proportion of advantageous decision-makers for the GDT had a linear relationship with delayed recall of the Hopkins Verbal Learning Test and Stroop color words (p < 0.01 and p < 0.01, respectively).ConclusionOur findings suggest that decision-making ability under ambiguity is compromised in MCI and AD, and the decision-making under risk is only impaired in AD. Reduced decision-making performance under risk is closely correlated with lower executive functions and memory.https://www.frontiersin.org/article/10.3389/fpsyt.2020.00218/fulldecision-makingAlzheimer’s diseasemild cognitive impairmentexecutive functionmemory |
| spellingShingle | Tingting Sun Tingting Sun Teng Xie Teng Xie Jing Wang Jing Wang Long Zhang Yanghua Tian Kai Wang Xin Yu Xin Yu Huali Wang Huali Wang Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment Frontiers in Psychiatry decision-making Alzheimer’s disease mild cognitive impairment executive function memory |
| title | Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment |
| title_full | Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment |
| title_fullStr | Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment |
| title_full_unstemmed | Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment |
| title_short | Decision-Making Under Ambiguity or Risk in Individuals With Alzheimer’s Disease and Mild Cognitive Impairment |
| title_sort | decision making under ambiguity or risk in individuals with alzheimer s disease and mild cognitive impairment |
| topic | decision-making Alzheimer’s disease mild cognitive impairment executive function memory |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.00218/full |
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