Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues
Background Research into neural mechanisms underlying cue-induced cigarette craving has attracted considerable attention for its significant role in treatments. However, there is little understanding about the effects of exposure to smoking-related cues on electroencephalogram (EEG) microstates of s...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2023-03-01
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| Series: | BJPsych Open |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S205647242200641X/type/journal_article |
| _version_ | 1811156857626034176 |
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| author | Hefan Gan Junjie Bu Ginger Qinghong Zeng Huixing Gou Mengyuan Liu Guanbao Cui Xiaochu Zhang |
| author_facet | Hefan Gan Junjie Bu Ginger Qinghong Zeng Huixing Gou Mengyuan Liu Guanbao Cui Xiaochu Zhang |
| author_sort | Hefan Gan |
| collection | DOAJ |
| description | Background
Research into neural mechanisms underlying cue-induced cigarette craving has attracted considerable attention for its significant role in treatments. However, there is little understanding about the effects of exposure to smoking-related cues on electroencephalogram (EEG) microstates of smokers, which can reflect abnormal brain network activity in several psychiatric disorders.
Aims
To explore whether abnormal brain network activity in smokers on exposure to smoking-related cues would be captured by EEG microstates.
Method
Forty smokers were exposed to smoking and neutral imagery conditions (cues) during EEG recording. Behavioural data and parameters for microstate topographies associated with the auditory (A), visual (B), salience and memory (C) and dorsal attention networks (D) were compared between conditions. Correlations between microstate parameters and cigarette craving as well as nicotine addiction characteristics were also analysed.
Results
The smoking condition elicited a significant increase in the duration of microstate classes B and C and in the duration and contribution of class D compared with the neutral condition. A significant positive correlation between the increased duration of class C (smoking minus neutral) and increased craving ratings was observed, which was fully mediated by increased posterior alpha power. The increased duration and contribution of class D were both positively correlated with years of smoking.
Conclusions
Our results indicate that smokers showed abnormal EEG microstates when exposed to smoking-related cues compared with neutral cues. Importantly, microstate class C (duration) might be a biomarker of cue-induced cigarette craving, and class D (duration and contribution) might reflect the relationship between cue-elicited activation of the dorsal attention network and years of smoking.
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| first_indexed | 2024-04-10T04:58:08Z |
| format | Article |
| id | doaj.art-7d19345c66b948cb92bb7beac785d7ff |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T04:58:08Z |
| publishDate | 2023-03-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-7d19345c66b948cb92bb7beac785d7ff2023-03-09T12:29:28ZengCambridge University PressBJPsych Open2056-47242023-03-01910.1192/bjo.2022.641Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cuesHefan Gan0Junjie Bu1Ginger Qinghong Zeng2Huixing Gou3Mengyuan Liu4Guanbao Cui5Xiaochu Zhang6https://orcid.org/0000-0002-7541-0130Department of Radiology, the First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, ChinaSchool of Biomedical Engineering, Anhui Medical University, Hefei, ChinaInstitute of Advanced Technology, University of Science and Technology of China, Hefei, ChinaDepartment of Radiology, the First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, ChinaDepartment of Psychology, School of Humanities and Social Science, University of Science and Technology of China, Hefei, ChinaApplication Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science and Technology of China, Hefei, ChinaDepartment of Radiology, the First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale and School of Life Science, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China; Department of Psychology, School of Humanities and Social Science, University of Science and Technology of China, Hefei, China; Application Technology Center of Physical Therapy to Brain Disorders, Institute of Advanced Technology, University of Science and Technology of China, Hefei, China; Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei, China.Background Research into neural mechanisms underlying cue-induced cigarette craving has attracted considerable attention for its significant role in treatments. However, there is little understanding about the effects of exposure to smoking-related cues on electroencephalogram (EEG) microstates of smokers, which can reflect abnormal brain network activity in several psychiatric disorders. Aims To explore whether abnormal brain network activity in smokers on exposure to smoking-related cues would be captured by EEG microstates. Method Forty smokers were exposed to smoking and neutral imagery conditions (cues) during EEG recording. Behavioural data and parameters for microstate topographies associated with the auditory (A), visual (B), salience and memory (C) and dorsal attention networks (D) were compared between conditions. Correlations between microstate parameters and cigarette craving as well as nicotine addiction characteristics were also analysed. Results The smoking condition elicited a significant increase in the duration of microstate classes B and C and in the duration and contribution of class D compared with the neutral condition. A significant positive correlation between the increased duration of class C (smoking minus neutral) and increased craving ratings was observed, which was fully mediated by increased posterior alpha power. The increased duration and contribution of class D were both positively correlated with years of smoking. Conclusions Our results indicate that smokers showed abnormal EEG microstates when exposed to smoking-related cues compared with neutral cues. Importantly, microstate class C (duration) might be a biomarker of cue-induced cigarette craving, and class D (duration and contribution) might reflect the relationship between cue-elicited activation of the dorsal attention network and years of smoking. https://www.cambridge.org/core/product/identifier/S205647242200641X/type/journal_articleNicotine-dependent smokerssmoking cue reactivityimagery scriptscue-induced cravingEEG microstate analysis |
| spellingShingle | Hefan Gan Junjie Bu Ginger Qinghong Zeng Huixing Gou Mengyuan Liu Guanbao Cui Xiaochu Zhang Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues BJPsych Open Nicotine-dependent smokers smoking cue reactivity imagery scripts cue-induced craving EEG microstate analysis |
| title | Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues |
| title_full | Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues |
| title_fullStr | Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues |
| title_full_unstemmed | Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues |
| title_short | Correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking-related cues |
| title_sort | correlation between abnormal brain network activity and electroencephalogram microstates on exposure to smoking related cues |
| topic | Nicotine-dependent smokers smoking cue reactivity imagery scripts cue-induced craving EEG microstate analysis |
| url | https://www.cambridge.org/core/product/identifier/S205647242200641X/type/journal_article |
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