Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone
AbstractBackground The range of an ablation zone (AZ) plays a crucial role in the treatment effect of microwave ablation (MWA). The aim of this study was to analyze the factors influencing the AZ range.Methods Fourteen factors in four areas were included: patient-related factors (sex, age), disease-...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2023.2181843 |
| _version_ | 1797374227455672320 |
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| author | Wen-zhen Ding Hao Wei Jia-peng Wu Zhi-gang Cheng Zhi-yu Han Fang-yi Liu Jie Yu Ping Liang |
| author_facet | Wen-zhen Ding Hao Wei Jia-peng Wu Zhi-gang Cheng Zhi-yu Han Fang-yi Liu Jie Yu Ping Liang |
| author_sort | Wen-zhen Ding |
| collection | DOAJ |
| description | AbstractBackground The range of an ablation zone (AZ) plays a crucial role in the treatment effect of microwave ablation (MWA). The aim of this study was to analyze the factors influencing the AZ range.Methods Fourteen factors in four areas were included: patient-related factors (sex, age), disease-related factors (tumor location, liver cirrhosis), serological factors (ALT, AST, total protein, albumin, total bilirubin, direct bilirubin, and platelets), and MWA parameters (ablation time, power, and needle type). Multiple sequence MRI was used to delineate AZ by three radiologists using 3D Slicer. MATLAB was used to calculate the AZ length, width, and area of the largest section. Linear regression analysis was used to analyze influencing factors. Moreover, a subgroup analysis was conducted for patients with viral hepatitis.Result 220 patients with 290 tumors were included between 2010–2021. In addition to MWA parameters, cirrhosis and tumor location were significant factors that influenced AZ (p < 0.001). The standardized coefficient (beta) of cirrhosis (cirrhosis vs. non-cirrhosis) was positive, which meant cirrhosis would lead to a decrease in AZ range. The beta of tumor location (near the hepatic hilar zone, intermediate zone, and periphery zone) was negative, indicating that AZ range decreased as the tumor location approached the hepatic hilum. For viral hepatitis patients, Fibrosis 4 (FIB4) score was a significant factor influencing AZ (p < 0.001), and the beta was negative, indicating that AZ range decreased as FIB4 increased.Conclusion Liver cirrhosis, tumor location, and FIB4 affect the AZ range and should be considered when planning MWA parameters. |
| first_indexed | 2024-03-08T19:02:52Z |
| format | Article |
| id | doaj.art-7d19501415f04696a399660fab97f892 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-03-08T19:02:52Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-7d19501415f04696a399660fab97f8922023-12-28T04:15:43ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572023-12-0140110.1080/02656736.2023.2181843Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zoneWen-zhen Ding0Hao Wei1Jia-peng Wu2Zhi-gang Cheng3Zhi-yu Han4Fang-yi Liu5Jie Yu6Ping Liang7Fifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaSchool of Biological Science and Medical Engineering, Southeast University, Nanjing, Jiangsu, ChinaFifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaFifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaFifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaFifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaFifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaFifth Medical Center of Chinese, PLA General Hospital, Beijing, ChinaAbstractBackground The range of an ablation zone (AZ) plays a crucial role in the treatment effect of microwave ablation (MWA). The aim of this study was to analyze the factors influencing the AZ range.Methods Fourteen factors in four areas were included: patient-related factors (sex, age), disease-related factors (tumor location, liver cirrhosis), serological factors (ALT, AST, total protein, albumin, total bilirubin, direct bilirubin, and platelets), and MWA parameters (ablation time, power, and needle type). Multiple sequence MRI was used to delineate AZ by three radiologists using 3D Slicer. MATLAB was used to calculate the AZ length, width, and area of the largest section. Linear regression analysis was used to analyze influencing factors. Moreover, a subgroup analysis was conducted for patients with viral hepatitis.Result 220 patients with 290 tumors were included between 2010–2021. In addition to MWA parameters, cirrhosis and tumor location were significant factors that influenced AZ (p < 0.001). The standardized coefficient (beta) of cirrhosis (cirrhosis vs. non-cirrhosis) was positive, which meant cirrhosis would lead to a decrease in AZ range. The beta of tumor location (near the hepatic hilar zone, intermediate zone, and periphery zone) was negative, indicating that AZ range decreased as the tumor location approached the hepatic hilum. For viral hepatitis patients, Fibrosis 4 (FIB4) score was a significant factor influencing AZ (p < 0.001), and the beta was negative, indicating that AZ range decreased as FIB4 increased.Conclusion Liver cirrhosis, tumor location, and FIB4 affect the AZ range and should be considered when planning MWA parameters.https://www.tandfonline.com/doi/10.1080/02656736.2023.2181843Microwave ablationablation zonecirrhosisliver tumor |
| spellingShingle | Wen-zhen Ding Hao Wei Jia-peng Wu Zhi-gang Cheng Zhi-yu Han Fang-yi Liu Jie Yu Ping Liang Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone International Journal of Hyperthermia Microwave ablation ablation zone cirrhosis liver tumor |
| title | Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone |
| title_full | Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone |
| title_fullStr | Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone |
| title_full_unstemmed | Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone |
| title_short | Liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone |
| title_sort | liver cirrhosis and tumor location can affect the range of intrahepatic microwave ablation zone |
| topic | Microwave ablation ablation zone cirrhosis liver tumor |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2023.2181843 |
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