Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis
Yeast Candida tropiclis had been used as a cell model to investigate effects of drugs in cell level. Phaleria macrocarpa (Scheff.) Boerl., is traditionally used in Indonesia as medicinal plant. This study was to evaluate the antioxidant property of P. macrocarpa in cell level by using yeast C. tro...
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| Format: | Article |
| Language: | English |
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Indonesian Biological Society
2012-10-01
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| Series: | Journal of Biological Researches |
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| Online Access: | http://berkalahayati.org/journal/33509073 |
| _version_ | 1811218011730739200 |
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| author | Heddy Julistiono |
| author_facet | Heddy Julistiono |
| author_sort | Heddy Julistiono |
| collection | DOAJ |
| description | Yeast Candida tropiclis had been used as a cell model to investigate effects of drugs in cell level. Phaleria macrocarpa (Scheff.) Boerl., is traditionally used in Indonesia as medicinal plant. This study was to evaluate the antioxidant property of P. macrocarpa in cell level by using yeast C. tropicalis induced with ferric citrate. Ferric citrate of 1 mM or 5 mM induced oxidative stress inthe the yeast, marked with increasing of an oxidative damage marker, malon dialdehyde (MDA). Concentration of 5 mM of Ferric citrate caused cell mortality but concentration of 1 mM did not affect cell viability. Hot water extract of P. macrocarpa of 1 mg/ml attenuated MDA level in yeast cell induced with 1 mM ferric citrate. Whereas, 1 mg/ml of P. macrocarpa decreased cell mortality of the yeast induced with 5 mM ferric citrate with out decreasing level of MDA. However, 4 mg/ml of P. macrocarpa induced oxidative damage in yeast cell. The data may indicate the potential use of Indonesian traditional plant P. macrocarpa as herbal medicine for protecting human cell from oxidation damage. |
| first_indexed | 2024-04-12T07:03:58Z |
| format | Article |
| id | doaj.art-7d1957cc93b8438a93bb8244e7c40699 |
| institution | Directory Open Access Journal |
| issn | 0852-6834 2337-389X |
| language | English |
| last_indexed | 2024-04-12T07:03:58Z |
| publishDate | 2012-10-01 |
| publisher | Indonesian Biological Society |
| record_format | Article |
| series | Journal of Biological Researches |
| spelling | doaj.art-7d1957cc93b8438a93bb8244e7c406992022-12-22T03:42:56ZengIndonesian Biological SocietyJournal of Biological Researches0852-68342337-389X2012-10-01171737610.23869/bphjbr.17.1.201114Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalisHeddy Julistiono0Bidang Mikrobiologi, Pusat Penelitian Biologi LIPI, Cibinong Science Center, IndonesiaYeast Candida tropiclis had been used as a cell model to investigate effects of drugs in cell level. Phaleria macrocarpa (Scheff.) Boerl., is traditionally used in Indonesia as medicinal plant. This study was to evaluate the antioxidant property of P. macrocarpa in cell level by using yeast C. tropicalis induced with ferric citrate. Ferric citrate of 1 mM or 5 mM induced oxidative stress inthe the yeast, marked with increasing of an oxidative damage marker, malon dialdehyde (MDA). Concentration of 5 mM of Ferric citrate caused cell mortality but concentration of 1 mM did not affect cell viability. Hot water extract of P. macrocarpa of 1 mg/ml attenuated MDA level in yeast cell induced with 1 mM ferric citrate. Whereas, 1 mg/ml of P. macrocarpa decreased cell mortality of the yeast induced with 5 mM ferric citrate with out decreasing level of MDA. However, 4 mg/ml of P. macrocarpa induced oxidative damage in yeast cell. The data may indicate the potential use of Indonesian traditional plant P. macrocarpa as herbal medicine for protecting human cell from oxidation damage.http://berkalahayati.org/journal/33509073AntioxidantCandida tropicalisOxidative StressPhaleria macrocarpa |
| spellingShingle | Heddy Julistiono Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis Journal of Biological Researches Antioxidant Candida tropicalis Oxidative Stress Phaleria macrocarpa |
| title | Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis |
| title_full | Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis |
| title_fullStr | Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis |
| title_full_unstemmed | Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis |
| title_short | Efek Proteksi Ekstrak Air Panas Buah Mahkota Dewa Phaleria macrocarpa SCHEFF. BOERL. terhadap Stres Oksidasi akibat Ferri Sitrat pada Khamir Candida tropicalis |
| title_sort | efek proteksi ekstrak air panas buah mahkota dewa phaleria macrocarpa scheff boerl terhadap stres oksidasi akibat ferri sitrat pada khamir candida tropicalis |
| topic | Antioxidant Candida tropicalis Oxidative Stress Phaleria macrocarpa |
| url | http://berkalahayati.org/journal/33509073 |
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