Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris
<b>Objectives:</b> Acne is a chronic inflammatory disease that affects the pilosebaceous units of the skin. Isotretinoin is a derivative of the synthetic 13-cis-retinoic acid and is an efficient drug for acne treatment. In clinical studies, the negative effects of long-term and...
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| Format: | Article |
| Language: | English |
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National Scientific Medical Center
2018-03-01
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| Series: | Ķazaķstannyṇ Klinikalyķ Medicinasy |
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| Online Access: | https://www.clinmedkaz.org/download/effect-of-6-month-isotretinoin-treatment-on-25-hydroxyvitamin-d-levels-in-patients-with-acne-8954.pdf |
| _version_ | 1818500767508594688 |
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| author | Gülbahar Saraç Tuba Tülay Koca Serpil Şener Gülden Hakverdi |
| author_facet | Gülbahar Saraç Tuba Tülay Koca Serpil Şener Gülden Hakverdi |
| author_sort | Gülbahar Saraç |
| collection | DOAJ |
| description | <b>Objectives:</b> Acne is a chronic inflammatory disease that affects the pilosebaceous units of the skin. Isotretinoin is a derivative of the synthetic 13-cis-retinoic acid and is an efficient drug for acne treatment. In clinical studies, the negative effects of long-term and short-term isotretinoin use on vitamin D levels and bone metabolism restrict its use. In this study, the effect of isotretinoin treatment on vitamin D levels was examined in patients with acne vulgaris.<br>
<b>Material and Methods:</b> Ninety patients with clinically diagnosed acne vulgaris who came to the Malatya Research and Training Hospital Dermatology Clinic participated in this study. Patients who had been using any systemic drug for the previous month or who had any systemic disease were not included in the study. Patients with abnormalities in calcium (Ca), alkaline phosphatase (ALP), and parathyroid hormone (PTH) levels, which affect vitamin D metabolism, also were not included in the study. Patients were treated first with 0.5 to 1.0 mg/kg (per kilogram of body weight) doses of isotretinoin, with the aim of total dosage of 120 mg/kg. The patients’ 25-hydroxy vitamin D<sub>3</sub> [25'(OH) vit D<sub>3</sub>] levels were measured before treatment and at the sixth month of treatment.<br>
<b>Results:</b> Among the 90 patients who participated in the study, 51 (56.7%) were female, and 39 (43.3%) were male, with an age range of 16 to 50 years (mean ±standard deviation) age, 23.55±5.58 years. Eight patients dropped out of the study. The patients’ (mean ± standard deviation) 25'(OH) vit D<sub>3</sub> level was 18.28±9.92 before treatment and 13.28±7.78 at the sixth month of treatment (p=0.000).<br>
<b>Conclusion:</b> The negative effect of isotretinoin on vitamin D levels and bone metabolism has been shown in previous studies. In this study, 25'(OH) vit D<sub>3</sub> levels decreased significantly in patients treated with isotretinoin in the long term (p>0.000). |
| first_indexed | 2024-12-10T20:47:14Z |
| format | Article |
| id | doaj.art-7d1bb4ee7e3f487b9270fedb5f79b2a5 |
| institution | Directory Open Access Journal |
| issn | 1812-2892 2313-1519 |
| language | English |
| last_indexed | 2024-12-10T20:47:14Z |
| publishDate | 2018-03-01 |
| publisher | National Scientific Medical Center |
| record_format | Article |
| series | Ķazaķstannyṇ Klinikalyķ Medicinasy |
| spelling | doaj.art-7d1bb4ee7e3f487b9270fedb5f79b2a52022-12-22T01:34:12ZengNational Scientific Medical CenterĶazaķstannyṇ Klinikalyķ Medicinasy1812-28922313-15192018-03-01147252810.23950/1812-2892-JCMK-00537Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne VulgarisGülbahar Saraç0Tuba Tülay Koca1Serpil Şener2Gülden Hakverdi3Department of Dermatology İnonu University, Malatya, TurkeyDepartment of Physical Medicine and Rehabilitation, Sütçü İmam University, Kahramanmaraş, TurkeyDepartment of Dermatology İnonu University, Malatya, TurkeyDepartment of Biostatistics, Cumhuriyet University, Sivas, Turkey<b>Objectives:</b> Acne is a chronic inflammatory disease that affects the pilosebaceous units of the skin. Isotretinoin is a derivative of the synthetic 13-cis-retinoic acid and is an efficient drug for acne treatment. In clinical studies, the negative effects of long-term and short-term isotretinoin use on vitamin D levels and bone metabolism restrict its use. In this study, the effect of isotretinoin treatment on vitamin D levels was examined in patients with acne vulgaris.<br> <b>Material and Methods:</b> Ninety patients with clinically diagnosed acne vulgaris who came to the Malatya Research and Training Hospital Dermatology Clinic participated in this study. Patients who had been using any systemic drug for the previous month or who had any systemic disease were not included in the study. Patients with abnormalities in calcium (Ca), alkaline phosphatase (ALP), and parathyroid hormone (PTH) levels, which affect vitamin D metabolism, also were not included in the study. Patients were treated first with 0.5 to 1.0 mg/kg (per kilogram of body weight) doses of isotretinoin, with the aim of total dosage of 120 mg/kg. The patients’ 25-hydroxy vitamin D<sub>3</sub> [25'(OH) vit D<sub>3</sub>] levels were measured before treatment and at the sixth month of treatment.<br> <b>Results:</b> Among the 90 patients who participated in the study, 51 (56.7%) were female, and 39 (43.3%) were male, with an age range of 16 to 50 years (mean ±standard deviation) age, 23.55±5.58 years. Eight patients dropped out of the study. The patients’ (mean ± standard deviation) 25'(OH) vit D<sub>3</sub> level was 18.28±9.92 before treatment and 13.28±7.78 at the sixth month of treatment (p=0.000).<br> <b>Conclusion:</b> The negative effect of isotretinoin on vitamin D levels and bone metabolism has been shown in previous studies. In this study, 25'(OH) vit D<sub>3</sub> levels decreased significantly in patients treated with isotretinoin in the long term (p>0.000).https://www.clinmedkaz.org/download/effect-of-6-month-isotretinoin-treatment-on-25-hydroxyvitamin-d-levels-in-patients-with-acne-8954.pdfvitamin Dacne vulgarisbone metabolism |
| spellingShingle | Gülbahar Saraç Tuba Tülay Koca Serpil Şener Gülden Hakverdi Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris Ķazaķstannyṇ Klinikalyķ Medicinasy vitamin D acne vulgaris bone metabolism |
| title | Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris |
| title_full | Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris |
| title_fullStr | Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris |
| title_full_unstemmed | Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris |
| title_short | Effect of 6-Month Isotretinoin Treatment on 25-Hydroxyvitamin D Levels in Patients With Acne Vulgaris |
| title_sort | effect of 6 month isotretinoin treatment on 25 hydroxyvitamin d levels in patients with acne vulgaris |
| topic | vitamin D acne vulgaris bone metabolism |
| url | https://www.clinmedkaz.org/download/effect-of-6-month-isotretinoin-treatment-on-25-hydroxyvitamin-d-levels-in-patients-with-acne-8954.pdf |
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