Four New Benzoylamide Derivatives Isolated from the Seeds of <i>Lepidium apetalum</i> Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
Four new benzoylamide derivatives, lepidiumamide B–E (<b>1</b>–<b>4</b>), were isolated from the seeds of <i>Lepidium apetalum</i> Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/3/722 |
| Summary: | Four new benzoylamide derivatives, lepidiumamide B–E (<b>1</b>–<b>4</b>), were isolated from the seeds of <i>Lepidium apetalum</i> Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury. |
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| ISSN: | 1420-3049 |