Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain
The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasti...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/11290 |
| _version_ | 1811180617232023552 |
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| author | Justyna Pielecka-Fortuna Evgenia Kalogeraki Michal G Fortuna Siegrid Löwel |
| author_facet | Justyna Pielecka-Fortuna Evgenia Kalogeraki Michal G Fortuna Siegrid Löwel |
| author_sort | Justyna Pielecka-Fortuna |
| collection | DOAJ |
| description | The ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur. |
| first_indexed | 2024-04-11T09:06:16Z |
| format | Article |
| id | doaj.art-7d1ff3005c3f4b47ba66c76f3d81fa48 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:06:16Z |
| publishDate | 2015-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-7d1ff3005c3f4b47ba66c76f3d81fa482022-12-22T04:32:37ZengeLife Sciences Publications LtdeLife2050-084X2015-11-01410.7554/eLife.11290Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brainJustyna Pielecka-Fortuna0Evgenia Kalogeraki1Michal G Fortuna2Siegrid Löwel3Department of Systems Neuroscience, Bernstein Focus Neurotechnology, Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology, University of Göttingen, Göttingen, GermanyDepartment of Systems Neuroscience, Bernstein Focus Neurotechnology, Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology, University of Göttingen, Göttingen, Germany; Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, University of Göttingen, Göttingen, GermanyInstitute for Neurophysiology and Cellular Biophysics, University Medical Center, Göttingen, Germany; German Primate Center, Göttingen, GermanyDepartment of Systems Neuroscience, Bernstein Focus Neurotechnology, Johann-Friedrich-Blumenbach Institute for Zoology and Anthropology, University of Göttingen, Göttingen, GermanyThe ability of the adult brain to undergo plastic changes is of particular interest in medicine, especially regarding recovery from injuries or improving learning and cognition. Matrix metalloproteinases (MMPs) have been associated with juvenile experience-dependent primary visual cortex (V1) plasticity, yet little is known about their role in this process in the adult V1. Activation of MMPs is a crucial step facilitating structural changes in a healthy brain; however, upon brain injury, upregulated MMPs promote the spread of a lesion and impair recovery. To clarify these seemingly opposing outcomes of MMP-activation, we examined the effects of MMP-inhibition on experience-induced plasticity in healthy and stoke-affected adult mice. In healthy animals, 7-day application of MMP-inhibitor prevented visual plasticity. Additionally, treatment with MMP-inhibitor once but not twice following stroke rescued plasticity, normally lost under these conditions. Our data imply that an optimal level of MMP-activity is crucial for adult visual plasticity to occur.https://elifesciences.org/articles/11290adult cortical plasticitymatrix metalloproteinasesprimary visual cortexstroke |
| spellingShingle | Justyna Pielecka-Fortuna Evgenia Kalogeraki Michal G Fortuna Siegrid Löwel Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain eLife adult cortical plasticity matrix metalloproteinases primary visual cortex stroke |
| title | Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain |
| title_full | Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain |
| title_fullStr | Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain |
| title_full_unstemmed | Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain |
| title_short | Optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke-affected brain |
| title_sort | optimal level activity of matrix metalloproteinases is critical for adult visual plasticity in the healthy and stroke affected brain |
| topic | adult cortical plasticity matrix metalloproteinases primary visual cortex stroke |
| url | https://elifesciences.org/articles/11290 |
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