The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction

The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction

During the last three decades, timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous intervention (pPCI) has allowed amazing improvements in outcomes with a more than halving in 1-year ST-elevation myocardial infarction (STEMI) mortality. However, mortality and left...

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Bibliographic Details
Main Authors: Alessandro Bellis, Ciro Mauro, Emanuele Barbato, Giuseppe Di Gioia, Daniela Sorriento, Bruno Trimarco, Carmine Morisco
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
neprilysin
myocardial ischemia-reperfusion injury
natriuretic peptide
angiotensin II
bradykinin
apelin
Online Access:https://www.mdpi.com/2073-4409/9/9/2134

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