Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study
PurposeBasal metabolic rate may play a key role in the pathogenesis and progression of osteoporosis. We performed Mendelian random analysis to evaluate the causal relationship between basal metabolic rate and osteoporosis.MethodsInstrumental variables for the basal metabolic rate were selected. We u...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1096519/full |
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| author | Jingyu Zhou Zhiwen Ye Zhiwen Ye Zhiwen Ye Peng Wei Feng Yi Min Ouyang Shilang Xiong Yayun Liu Jintang Li Min Liu Hanrui Xi Qianyi Peng Qianyi Peng Qianyi Peng Long Xiong |
| author_facet | Jingyu Zhou Zhiwen Ye Zhiwen Ye Zhiwen Ye Peng Wei Feng Yi Min Ouyang Shilang Xiong Yayun Liu Jintang Li Min Liu Hanrui Xi Qianyi Peng Qianyi Peng Qianyi Peng Long Xiong |
| author_sort | Jingyu Zhou |
| collection | DOAJ |
| description | PurposeBasal metabolic rate may play a key role in the pathogenesis and progression of osteoporosis. We performed Mendelian random analysis to evaluate the causal relationship between basal metabolic rate and osteoporosis.MethodsInstrumental variables for the basal metabolic rate were selected. We used the inverse variance weighting approach as the main Mendelian random analysis method to estimate causal effects based on the summary-level data for osteoporosis from genome-wide association studies.ResultsA potential causal association was observed between basal metabolic rate and risks of osteoporosis (odds ratio = 0.9923, 95% confidence interval: 0.9898–0.9949; P = 4.005e − 09). The secondary MR also revealed that BMR was causally associated with osteoporosis (odds ratio = 0.9939, 95% confidence interval: 0.9911–0.9966; P = 1.038e − 05). The accuracy and robustness of the findings were confirmed using sensitivity tests.ConclusionBasal metabolic rate may play a causal role in the development of osteoporosis, although the underlying mechanisms require further investigation. |
| first_indexed | 2024-04-10T18:51:32Z |
| format | Article |
| id | doaj.art-7d22224171f44183b8251c009e5002f3 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-10T18:51:32Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-7d22224171f44183b8251c009e5002f32023-02-01T06:51:26ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-02-011110.3389/fpubh.2023.10965191096519Effect of basal metabolic rate on osteoporosis: A Mendelian randomization studyJingyu Zhou0Zhiwen Ye1Zhiwen Ye2Zhiwen Ye3Peng Wei4Feng Yi5Min Ouyang6Shilang Xiong7Yayun Liu8Jintang Li9Min Liu10Hanrui Xi11Qianyi Peng12Qianyi Peng13Qianyi Peng14Long Xiong15Department of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, ChinaHunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, People's Hospital Affiliated with Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, People's Hospital Affiliated with Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, ChinaHunan Provincial Clinical Research Center for Critical Care Medicine, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopaedics, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, ChinaPurposeBasal metabolic rate may play a key role in the pathogenesis and progression of osteoporosis. We performed Mendelian random analysis to evaluate the causal relationship between basal metabolic rate and osteoporosis.MethodsInstrumental variables for the basal metabolic rate were selected. We used the inverse variance weighting approach as the main Mendelian random analysis method to estimate causal effects based on the summary-level data for osteoporosis from genome-wide association studies.ResultsA potential causal association was observed between basal metabolic rate and risks of osteoporosis (odds ratio = 0.9923, 95% confidence interval: 0.9898–0.9949; P = 4.005e − 09). The secondary MR also revealed that BMR was causally associated with osteoporosis (odds ratio = 0.9939, 95% confidence interval: 0.9911–0.9966; P = 1.038e − 05). The accuracy and robustness of the findings were confirmed using sensitivity tests.ConclusionBasal metabolic rate may play a causal role in the development of osteoporosis, although the underlying mechanisms require further investigation.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1096519/fullbasal metabolic rateosteoporosisgenome-wide association studyMendelian randomizationaging |
| spellingShingle | Jingyu Zhou Zhiwen Ye Zhiwen Ye Zhiwen Ye Peng Wei Feng Yi Min Ouyang Shilang Xiong Yayun Liu Jintang Li Min Liu Hanrui Xi Qianyi Peng Qianyi Peng Qianyi Peng Long Xiong Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study Frontiers in Public Health basal metabolic rate osteoporosis genome-wide association study Mendelian randomization aging |
| title | Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study |
| title_full | Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study |
| title_fullStr | Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study |
| title_full_unstemmed | Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study |
| title_short | Effect of basal metabolic rate on osteoporosis: A Mendelian randomization study |
| title_sort | effect of basal metabolic rate on osteoporosis a mendelian randomization study |
| topic | basal metabolic rate osteoporosis genome-wide association study Mendelian randomization aging |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1096519/full |
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