Major Factors for the Persistent Folding of Hybrid α, β, γ-Hybrid Peptides Into Hairpins

Major Factors for the Persistent Folding of Hybrid α, β, γ-Hybrid Peptides Into Hairpins

Factors responsible for the persistent adoption of hairpin conformations by hybrid oligopeptides, each having a central β/α dipeptide segment flanked by aromatic γ-amino acid (γAr) residues, are probed. Our recent studies revealed that tetrapeptide 1 and 2, having central dipeptide segments consisti...

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Bibliographic Details
Main Authors: Yulong Zhong, Quan Tang, Daniel P. Miller, Eva Zurek, Rui Liu, Zhong-Lin Lu, Bing Gong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Chemistry
Subjects:
hybrid peptide
foldamer
hydrogen bond
β-turn
unnatural amino acid
β-hairpin
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.530083/full

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