<i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient
<i>Penicillium digitatum</i> is one of the most important phytopathogens. It causes deterioration and rotting of citrus fruits, generating significant economic losses worldwide. As a human pathogen, it is extremely rare. We present a case of pulmonary co-infection in a patient diagnosed...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/8/9/961 |
| _version_ | 1797486231277273088 |
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| author | Isabel Iturrieta-González Annesi Giacaman Patricio Godoy-Martínez Fernando Vega Marcela Sepúlveda Cledir Santos Valentina Toledo Gonzalo Rivera Leandro Ortega Andrés San Martín Vitalia Bahamondes Felipe Collao Raúl Sánchez Flery Fonseca-Salamanca |
| author_facet | Isabel Iturrieta-González Annesi Giacaman Patricio Godoy-Martínez Fernando Vega Marcela Sepúlveda Cledir Santos Valentina Toledo Gonzalo Rivera Leandro Ortega Andrés San Martín Vitalia Bahamondes Felipe Collao Raúl Sánchez Flery Fonseca-Salamanca |
| author_sort | Isabel Iturrieta-González |
| collection | DOAJ |
| description | <i>Penicillium digitatum</i> is one of the most important phytopathogens. It causes deterioration and rotting of citrus fruits, generating significant economic losses worldwide. As a human pathogen, it is extremely rare. We present a case of pulmonary co-infection in a patient diagnosed with pneumonia due to SARS-CoV-2. A 20-year-old female patient, primigravid, 36 weeks of gestation, without comorbidities, and diagnosed with severe pneumonia due to the SARS-CoV-2, showed rapid lung deterioration for which their pregnancy was interrupted by surgery. The patient was hospitalized in the Intensive Care Unit (ICU), connected to mechanical ventilation and receiving corticosteroids and antibiotics. The diagnosis of pulmonary fungal infection was made through bronchoalveolar lavage (BAL) culture, and the species identification was performed by sequencing of β-tubulin. Phylogenetic analysis with related species was performed for the confirmation of species identification. Antifungal susceptibility tests were performed for itraconazole (4 µg/mL), voriconazole (2 µg/mL), and amphotericin B (2 µg/mL). The patient was successfully treated with itraconazole. This is the second worldwide report of pulmonary infection by <i>P. digitatum</i> and the first in Chile. Although it is a fungus that rarely infects humans, it could represent an emerging opportunistic fungal pathogen, with associated risk factors that should be considered in the differential diagnosis of <i>Penicillium</i> species isolated from infections in humans. |
| first_indexed | 2024-03-09T23:30:17Z |
| format | Article |
| id | doaj.art-7d26e24a97a640d488fe1aed5ec56068 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T23:30:17Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-7d26e24a97a640d488fe1aed5ec560682023-11-23T17:09:57ZengMDPI AGJournal of Fungi2309-608X2022-09-018996110.3390/jof8090961<i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 PatientIsabel Iturrieta-González0Annesi Giacaman1Patricio Godoy-Martínez2Fernando Vega3Marcela Sepúlveda4Cledir Santos5Valentina Toledo6Gonzalo Rivera7Leandro Ortega8Andrés San Martín9Vitalia Bahamondes10Felipe Collao11Raúl Sánchez12Flery Fonseca-Salamanca13Department of Preclinic Sciences, Medicine Faculty, Laboratory of Molecular Immunoparasitology, Center of Excellence in Translational Medicine-Scientific and Technological Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4810296, ChileJeffrey Modell Center of Diagnosis and Research in Primary Immunodeficiencies, Center of Excellence in Translational Medicine, Faculty of Medicine, Universidad de La Frontera, Temuco 4810296, ChileInstituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Valdivia 5110566, ChileUnidad de Paciente Crítico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileDepartment of Chemical Science and Natural Resources, Universidad de La Frontera, Temuco 4811230, ChileDepartment of Chemical Science and Natural Resources, Universidad de La Frontera, Temuco 4811230, ChileUnidad de Paciente Crítico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileUnidad de Paciente Crítico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileUnidad de Paciente Crítico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileSubdepartamento Laboratorio Clínico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileSubdepartamento Laboratorio Clínico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileSubdepartamento Laboratorio Clínico, Hospital Dr. Hernán Henríquez Aravena, Temuco 4781151, ChileDepartment of Preclinic Sciences, Medicine Faculty, Center of Excellence in Translational Medicine-Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4810296, ChileDepartment of Preclinic Sciences, Medicine Faculty, Laboratory of Molecular Immunoparasitology, Center of Excellence in Translational Medicine-Scientific and Technological Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4810296, Chile<i>Penicillium digitatum</i> is one of the most important phytopathogens. It causes deterioration and rotting of citrus fruits, generating significant economic losses worldwide. As a human pathogen, it is extremely rare. We present a case of pulmonary co-infection in a patient diagnosed with pneumonia due to SARS-CoV-2. A 20-year-old female patient, primigravid, 36 weeks of gestation, without comorbidities, and diagnosed with severe pneumonia due to the SARS-CoV-2, showed rapid lung deterioration for which their pregnancy was interrupted by surgery. The patient was hospitalized in the Intensive Care Unit (ICU), connected to mechanical ventilation and receiving corticosteroids and antibiotics. The diagnosis of pulmonary fungal infection was made through bronchoalveolar lavage (BAL) culture, and the species identification was performed by sequencing of β-tubulin. Phylogenetic analysis with related species was performed for the confirmation of species identification. Antifungal susceptibility tests were performed for itraconazole (4 µg/mL), voriconazole (2 µg/mL), and amphotericin B (2 µg/mL). The patient was successfully treated with itraconazole. This is the second worldwide report of pulmonary infection by <i>P. digitatum</i> and the first in Chile. Although it is a fungus that rarely infects humans, it could represent an emerging opportunistic fungal pathogen, with associated risk factors that should be considered in the differential diagnosis of <i>Penicillium</i> species isolated from infections in humans.https://www.mdpi.com/2309-608X/8/9/961<i>Penicillium digitatum</i>COVID-19pulmonar infectionpneumonia |
| spellingShingle | Isabel Iturrieta-González Annesi Giacaman Patricio Godoy-Martínez Fernando Vega Marcela Sepúlveda Cledir Santos Valentina Toledo Gonzalo Rivera Leandro Ortega Andrés San Martín Vitalia Bahamondes Felipe Collao Raúl Sánchez Flery Fonseca-Salamanca <i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient Journal of Fungi <i>Penicillium digitatum</i> COVID-19 pulmonar infection pneumonia |
| title | <i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient |
| title_full | <i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient |
| title_fullStr | <i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient |
| title_full_unstemmed | <i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient |
| title_short | <i>Penicillium digitatum</i>, First Clinical Report in Chile: Fungal Co-Infection in COVID-19 Patient |
| title_sort | i penicillium digitatum i first clinical report in chile fungal co infection in covid 19 patient |
| topic | <i>Penicillium digitatum</i> COVID-19 pulmonar infection pneumonia |
| url | https://www.mdpi.com/2309-608X/8/9/961 |
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