Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial
<b>Purpose:</b> To compare the efficacy in pupil dilatation between a mixture containing 0.75% tropicamide and 2.5% phenylephrine and the alternate application of 1% tropicamide and 10% phenylephrine eye drops. <b> Material and Methods&l...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2009-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=5;spage=351;epage=354;aulast=Trinavarat |
| _version_ | 1818018199252238336 |
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| author | Trinavarat Adisak Pituksung Auengporn |
| author_facet | Trinavarat Adisak Pituksung Auengporn |
| author_sort | Trinavarat Adisak |
| collection | DOAJ |
| description | <b>Purpose:</b> To compare the efficacy in pupil dilatation between a mixture containing 0.75% tropicamide and 2.5% phenylephrine and the alternate application of 1% tropicamide and 10% phenylephrine eye drops. <b> Material and Methods</b> : Patients requiring pupil dilatation were randomized to receive one drop of the mixture every 10 min for four times or our standard application of one drop of 1% tropicamide alternating with one drop of 10% phenylephrine every 10 min for two cycles. Pupil size was measured under bright light with the pupil gauge before, and every 5 min after initial application for 40 min. Application of the drops was discontinued once the pupil diameter reached 7 mm. Blood pressure and pulse rate were monitored every 15 min. <b> Results:</b> Of 40 patients (age 57.3±10.9 years, range 35-70 years), 22 were randomized into the mixture group and 18 into the alternate drug group. Baseline pupil sizes were 1.7±0.5 mm in the mixture group and 1.8±0.4 mm in the alternate drug group. The pupils were successfully dilated to 7 mm within 40 min in 17 patients of the mixture group compared to seven patients in the alternate drug group (<i> P</i> =0.004, Log Rank test). The mean pupil sizes at 40 min were 6.6±0.8 and 6.0±0.9 mm in the mixture and alternate drug groups respectively (<i> P</i> =0.050, t-test). Blood pressure and pulse rate were stable and similar in both groups. <b>Conclusions:</b> The mixture of 0.75% tropicamide and 2.5% phenylephrine is superior to our standard application of 1% tropicamide alternating with 10% phenylephrine. It provides faster and more successful pupil dilatation within 40 min. |
| first_indexed | 2024-04-14T07:36:50Z |
| format | Article |
| id | doaj.art-7d276cdce2834a6cb86bb2ee24d9594f |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-14T07:36:50Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-7d276cdce2834a6cb86bb2ee24d9594f2022-12-22T02:05:40ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892009-01-01575351354Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trialTrinavarat AdisakPituksung Auengporn<b>Purpose:</b> To compare the efficacy in pupil dilatation between a mixture containing 0.75% tropicamide and 2.5% phenylephrine and the alternate application of 1% tropicamide and 10% phenylephrine eye drops. <b> Material and Methods</b> : Patients requiring pupil dilatation were randomized to receive one drop of the mixture every 10 min for four times or our standard application of one drop of 1% tropicamide alternating with one drop of 10% phenylephrine every 10 min for two cycles. Pupil size was measured under bright light with the pupil gauge before, and every 5 min after initial application for 40 min. Application of the drops was discontinued once the pupil diameter reached 7 mm. Blood pressure and pulse rate were monitored every 15 min. <b> Results:</b> Of 40 patients (age 57.3±10.9 years, range 35-70 years), 22 were randomized into the mixture group and 18 into the alternate drug group. Baseline pupil sizes were 1.7±0.5 mm in the mixture group and 1.8±0.4 mm in the alternate drug group. The pupils were successfully dilated to 7 mm within 40 min in 17 patients of the mixture group compared to seven patients in the alternate drug group (<i> P</i> =0.004, Log Rank test). The mean pupil sizes at 40 min were 6.6±0.8 and 6.0±0.9 mm in the mixture and alternate drug groups respectively (<i> P</i> =0.050, t-test). Blood pressure and pulse rate were stable and similar in both groups. <b>Conclusions:</b> The mixture of 0.75% tropicamide and 2.5% phenylephrine is superior to our standard application of 1% tropicamide alternating with 10% phenylephrine. It provides faster and more successful pupil dilatation within 40 min.http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=5;spage=351;epage=354;aulast=TrinavaratMydriatricphenylephrinepupil dilatationtropicamide |
| spellingShingle | Trinavarat Adisak Pituksung Auengporn Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial Indian Journal of Ophthalmology Mydriatric phenylephrine pupil dilatation tropicamide |
| title | Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial |
| title_full | Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial |
| title_fullStr | Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial |
| title_full_unstemmed | Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial |
| title_short | Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial |
| title_sort | effective pupil dilatation with a mixture of 0 75 x0025 tropicamide and 2 5 x0025 phenylephrine a randomized controlled trial |
| topic | Mydriatric phenylephrine pupil dilatation tropicamide |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=5;spage=351;epage=354;aulast=Trinavarat |
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