New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria
Infectious diseases caused by clinically important Mycobacteria continue to be an important public health problem worldwide primarily due to emergence of drug resistance crisis. In recent years, the control of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (MTB), is hampered by...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.00681/full |
| _version_ | 1819058341911986176 |
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| author | Mohammad J. Nasiri Hossein Goudarzi Mehri Haeili Mona Ghazi Ali Pormohammad Abbas A. Imani Fooladi Mohammad M. Feizabadi Mohammad M. Feizabadi |
| author_facet | Mohammad J. Nasiri Hossein Goudarzi Mehri Haeili Mona Ghazi Ali Pormohammad Abbas A. Imani Fooladi Mohammad M. Feizabadi Mohammad M. Feizabadi |
| author_sort | Mohammad J. Nasiri |
| collection | DOAJ |
| description | Infectious diseases caused by clinically important Mycobacteria continue to be an important public health problem worldwide primarily due to emergence of drug resistance crisis. In recent years, the control of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (MTB), is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least isoniazid (INH) and rifampicin (RIF), two key drugs in the treatment of the disease. Despite the availability of curative anti-TB therapy, inappropriate and inadequate treatment has allowed MTB to acquire resistance to the most important anti-TB drugs. Likewise, for most mycobacteria other than MTB, the outcome of drug treatment is poor and is likely related to the high levels of antibiotic resistance. Thus, a better knowledge of the underlying mechanisms of drug resistance in mycobacteria could aid not only to select the best therapeutic options but also to develop novel drugs that can overwhelm the existing resistance mechanisms. In this article, we review the distinctive mechanisms of antibiotic resistance in mycobacteria. |
| first_indexed | 2024-12-21T13:53:40Z |
| format | Article |
| id | doaj.art-7d29954a4ecc4ea08aa1876a751f0a9b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-21T13:53:40Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-7d29954a4ecc4ea08aa1876a751f0a9b2022-12-21T19:01:37ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-04-01810.3389/fmicb.2017.00681251117New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in MycobacteriaMohammad J. Nasiri0Hossein Goudarzi1Mehri Haeili2Mona Ghazi3Ali Pormohammad4Abbas A. Imani Fooladi5Mohammad M. Feizabadi6Mohammad M. Feizabadi7Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesTehran, IranDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesTehran, IranDepartment of Biology, Faculty of Natural Sciences, University of TabrizTabriz, IranDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesTehran, IranDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesTehran, IranApplied Microbiology Research Center, Baqiyatallah University of Medical SciencesTehran, IranDepartment of Microbiology, School of Medicine, Tehran University of Medical SciencesTehran, IranThoracic Research Center, Imam Khomeini Hospital, Tehran University of Medical SciencesTehran, IranInfectious diseases caused by clinically important Mycobacteria continue to be an important public health problem worldwide primarily due to emergence of drug resistance crisis. In recent years, the control of tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (MTB), is hampered by the emergence of multidrug resistance (MDR), defined as resistance to at least isoniazid (INH) and rifampicin (RIF), two key drugs in the treatment of the disease. Despite the availability of curative anti-TB therapy, inappropriate and inadequate treatment has allowed MTB to acquire resistance to the most important anti-TB drugs. Likewise, for most mycobacteria other than MTB, the outcome of drug treatment is poor and is likely related to the high levels of antibiotic resistance. Thus, a better knowledge of the underlying mechanisms of drug resistance in mycobacteria could aid not only to select the best therapeutic options but also to develop novel drugs that can overwhelm the existing resistance mechanisms. In this article, we review the distinctive mechanisms of antibiotic resistance in mycobacteria.http://journal.frontiersin.org/article/10.3389/fmicb.2017.00681/fullMycobacteriumdrug resistanceresistancetuberculosisNontuberculous mycobacteria |
| spellingShingle | Mohammad J. Nasiri Hossein Goudarzi Mehri Haeili Mona Ghazi Ali Pormohammad Abbas A. Imani Fooladi Mohammad M. Feizabadi Mohammad M. Feizabadi New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria Frontiers in Microbiology Mycobacterium drug resistance resistance tuberculosis Nontuberculous mycobacteria |
| title | New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria |
| title_full | New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria |
| title_fullStr | New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria |
| title_full_unstemmed | New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria |
| title_short | New Insights in to the Intrinsic and Acquired Drug Resistance Mechanisms in Mycobacteria |
| title_sort | new insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria |
| topic | Mycobacterium drug resistance resistance tuberculosis Nontuberculous mycobacteria |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.00681/full |
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