Biosensors and sensors for dopamine detection
Abstract Dopamine is a key catecholamine neurotransmitter and it has critical roles in the function of the human central nervous system. Abnormal release of dopamine is related to neurological diseases and depression. Therefore, it is necessary to monitor dopamine levels in vivo and in real time to...
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| Format: | Article |
| Language: | English |
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Wiley
2021-02-01
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| Series: | View |
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| Online Access: | https://doi.org/10.1002/VIW.20200102 |
| _version_ | 1830353800534163456 |
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| author | Xixia Liu Juewen Liu |
| author_facet | Xixia Liu Juewen Liu |
| author_sort | Xixia Liu |
| collection | DOAJ |
| description | Abstract Dopamine is a key catecholamine neurotransmitter and it has critical roles in the function of the human central nervous system. Abnormal release of dopamine is related to neurological diseases and depression. Therefore, it is necessary to monitor dopamine levels in vivo and in real time to understand its physiological roles. In this review, we discuss dopamine detection focusing on the molecular recognition methods including enzymes, antibodies, and aptamers, as well as new advances based on nanomaterials and molecularly imprinted polymers (MIPs). A large fraction of these sensors rely on electrochemical detection to fulfill the requirement of fast, in situ, and in vivo detection with a high spatial and temporal resolution. These methods need to overcome interferences from molecules with a similar redox potential. In addition, fluorescent and colorimetric sensors based on aptamers are also quite popular, and care needs to be taken to validate specific dopamine binding. Combining aptamers or MIPs with electrochemistry promises to achieve rapid detection and increased selectivity. In this article, we pay more attention to the molecular recognition mechanism and critically review the sensor designs. In the end, some future directions are discussed. |
| first_indexed | 2024-12-20T01:20:45Z |
| format | Article |
| id | doaj.art-7d29aa865641456499419dee11aa01ee |
| institution | Directory Open Access Journal |
| issn | 2688-3988 2688-268X |
| language | English |
| last_indexed | 2024-12-20T01:20:45Z |
| publishDate | 2021-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj.art-7d29aa865641456499419dee11aa01ee2022-12-21T19:58:27ZengWileyView2688-39882688-268X2021-02-0121n/an/a10.1002/VIW.20200102Biosensors and sensors for dopamine detectionXixia Liu0Juewen Liu1Hubei Key Laboratory of Edible Wild Plants Conservation and Utilization Hubei Normal University Huangshi ChinaDepartment of Chemistry and Waterloo Institute for Nanotechnology University of Waterloo Waterloo CanadaAbstract Dopamine is a key catecholamine neurotransmitter and it has critical roles in the function of the human central nervous system. Abnormal release of dopamine is related to neurological diseases and depression. Therefore, it is necessary to monitor dopamine levels in vivo and in real time to understand its physiological roles. In this review, we discuss dopamine detection focusing on the molecular recognition methods including enzymes, antibodies, and aptamers, as well as new advances based on nanomaterials and molecularly imprinted polymers (MIPs). A large fraction of these sensors rely on electrochemical detection to fulfill the requirement of fast, in situ, and in vivo detection with a high spatial and temporal resolution. These methods need to overcome interferences from molecules with a similar redox potential. In addition, fluorescent and colorimetric sensors based on aptamers are also quite popular, and care needs to be taken to validate specific dopamine binding. Combining aptamers or MIPs with electrochemistry promises to achieve rapid detection and increased selectivity. In this article, we pay more attention to the molecular recognition mechanism and critically review the sensor designs. In the end, some future directions are discussed.https://doi.org/10.1002/VIW.20200102aptamerselectrochemistryenzymesfluorescenceneurotransmitters |
| spellingShingle | Xixia Liu Juewen Liu Biosensors and sensors for dopamine detection View aptamers electrochemistry enzymes fluorescence neurotransmitters |
| title | Biosensors and sensors for dopamine detection |
| title_full | Biosensors and sensors for dopamine detection |
| title_fullStr | Biosensors and sensors for dopamine detection |
| title_full_unstemmed | Biosensors and sensors for dopamine detection |
| title_short | Biosensors and sensors for dopamine detection |
| title_sort | biosensors and sensors for dopamine detection |
| topic | aptamers electrochemistry enzymes fluorescence neurotransmitters |
| url | https://doi.org/10.1002/VIW.20200102 |
| work_keys_str_mv | AT xixialiu biosensorsandsensorsfordopaminedetection AT juewenliu biosensorsandsensorsfordopaminedetection |