Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes

Role of Klotho and AGE/RAGE-Wnt/β-Catenin Signalling Pathway on the Development of Cardiac and Renal Fibrosis in Diabetes

Fibrosis plays an important role in the pathogenesis of long-term diabetic complications and contributes to the development of cardiac and renal dysfunction. The aim of this experimental study, performed in a long-term rat model, which resembles type 1 diabetes mellitus, was to investigate the role...

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Bibliographic Details
Main Authors: Beatriz Martín-Carro, Julia Martín-Vírgala, Sara Fernández-Villabrille, Alejandra Fernández-Fernández, Marcos Pérez-Basterrechea, Juan F. Navarro-González, Javier Donate-Correa, Carmen Mora-Fernández, Adriana S. Dusso, Natalia Carrillo-López, Sara Panizo, Manuel Naves-Díaz, José L. Fernández-Martín, Jorge B. Cannata-Andía, Cristina Alonso-Montes
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
sKlotho
sRAGE
AGEs
diabetes
T1DM
fibrosis
Online Access:https://www.mdpi.com/1422-0067/24/6/5241

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