Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment
There are increasing data about the association between bronchial asthma and obstructive sleep apnea (OSA) is an important contributor to asthma control and can aggravate asthma exacerbation, continuous positive airway pressure (CPAP) which is the main line of treatment in OSA can improve asthma out...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2013-01-01
|
| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763813000101 |
| _version_ | 1818111145291022336 |
|---|---|
| author | Hany Shaarawy Nasr Affara |
| author_facet | Hany Shaarawy Nasr Affara |
| author_sort | Hany Shaarawy |
| collection | DOAJ |
| description | There are increasing data about the association between bronchial asthma and obstructive sleep apnea (OSA) is an important contributor to asthma control and can aggravate asthma exacerbation, continuous positive airway pressure (CPAP) which is the main line of treatment in OSA can improve asthma outcomes.
Aim of the present study: To assess the prevalence of OSA in patients with stable uncontrolled asthma and to study the effect of CPAP treatment on the asthma condition.
Subjects and methods: Sixty subjects with uncontrolled bronchial asthma were included in the study, mean age was 46 ± 13 years, there were female predominance (75%), all patients were not smokers, pregnancy and patients in acute exacerbation were excluded, after detailed history taking and physical examination pulmonary function tests and asthma control test were applied to all patients to assess the asthma control, then polysomnography was done to all patients and those proved to have OSA were offered CPAP treatment and followed up for 6 weeks then assessed again for asthma control test, pulmonary function tests and day – time sleepiness.
Results: Fifteen patients out of the 60 patients included in the study proved to have OSA, Apnea Hypopnea Index (AHI) was 23.5 ± 10.9/h of sleep, CPAP treatment improved significantly the AHI (from 23.5 ± 10.9 to 2.3 ± 2.1/h of sleep, p < 0.01), but there was no significant improvement in asthma control test or in the pulmonary functions (ACT was 13.97 ± 3.52 before CPAP and became 14.1 ± 3.97, p > 0.05 after CPAP, FEV1% pred. was 60.1 ± 6.9 before CPAP and became 61.2 ± 6.2, p > 0.05 after CPAP.
Conclusion: Obstructive sleep apnea should be screened for in all patients with uncontrolled bronchial asthma, CPAP treatment may improve asthma quality of life but not improving the pulmonary function tests. Larger studies are needed to fully address the impact of CPAP on asthma condition in patient with both asthma and OSA. |
| first_indexed | 2024-12-11T02:58:23Z |
| format | Article |
| id | doaj.art-7d2f9c4b3abc4befb1d3d848ab3aa675 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-11T02:58:23Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-7d2f9c4b3abc4befb1d3d848ab3aa6752022-12-22T01:23:07ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382013-01-0162118318710.1016/j.ejcdt.2012.12.002Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatmentHany Shaarawy0Nasr Affara1Department of Chest Diseases, Alex University, EgyptDepartment of Chest Diseases, Zagazig University, EgyptThere are increasing data about the association between bronchial asthma and obstructive sleep apnea (OSA) is an important contributor to asthma control and can aggravate asthma exacerbation, continuous positive airway pressure (CPAP) which is the main line of treatment in OSA can improve asthma outcomes. Aim of the present study: To assess the prevalence of OSA in patients with stable uncontrolled asthma and to study the effect of CPAP treatment on the asthma condition. Subjects and methods: Sixty subjects with uncontrolled bronchial asthma were included in the study, mean age was 46 ± 13 years, there were female predominance (75%), all patients were not smokers, pregnancy and patients in acute exacerbation were excluded, after detailed history taking and physical examination pulmonary function tests and asthma control test were applied to all patients to assess the asthma control, then polysomnography was done to all patients and those proved to have OSA were offered CPAP treatment and followed up for 6 weeks then assessed again for asthma control test, pulmonary function tests and day – time sleepiness. Results: Fifteen patients out of the 60 patients included in the study proved to have OSA, Apnea Hypopnea Index (AHI) was 23.5 ± 10.9/h of sleep, CPAP treatment improved significantly the AHI (from 23.5 ± 10.9 to 2.3 ± 2.1/h of sleep, p < 0.01), but there was no significant improvement in asthma control test or in the pulmonary functions (ACT was 13.97 ± 3.52 before CPAP and became 14.1 ± 3.97, p > 0.05 after CPAP, FEV1% pred. was 60.1 ± 6.9 before CPAP and became 61.2 ± 6.2, p > 0.05 after CPAP. Conclusion: Obstructive sleep apnea should be screened for in all patients with uncontrolled bronchial asthma, CPAP treatment may improve asthma quality of life but not improving the pulmonary function tests. Larger studies are needed to fully address the impact of CPAP on asthma condition in patient with both asthma and OSA.http://www.sciencedirect.com/science/article/pii/S0422763813000101Bronchial asthmaOSACPAP |
| spellingShingle | Hany Shaarawy Nasr Affara Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment Egyptian Journal of Chest Disease and Tuberculosis Bronchial asthma OSA CPAP |
| title | Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment |
| title_full | Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment |
| title_fullStr | Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment |
| title_full_unstemmed | Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment |
| title_short | Assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma, impact of continuous positive airway pressure treatment |
| title_sort | assessment of the prevalence of obstructive sleep apnea in patients with stable uncontrolled asthma impact of continuous positive airway pressure treatment |
| topic | Bronchial asthma OSA CPAP |
| url | http://www.sciencedirect.com/science/article/pii/S0422763813000101 |
| work_keys_str_mv | AT hanyshaarawy assessmentoftheprevalenceofobstructivesleepapneainpatientswithstableuncontrolledasthmaimpactofcontinuouspositiveairwaypressuretreatment AT nasraffara assessmentoftheprevalenceofobstructivesleepapneainpatientswithstableuncontrolledasthmaimpactofcontinuouspositiveairwaypressuretreatment |