Prognostic significance of frailty status in patients with primary lung cancer
Abstract Lung cancer has one of the highest morbidity and mortality rates in the world. Frailty is common in many countries and is a major cause of premature functional decline and premature death in older adults, and may affect the treatment and prognosis of lung cancer patients. To investigate the...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | BMC Geriatrics |
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| Online Access: | https://doi.org/10.1186/s12877-023-03765-w |
| _version_ | 1811175694618591232 |
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| author | Kai Wang Quan She Min Li Hongye Zhao Weihong Zhao Bo Chen Jianqing Wu |
| author_facet | Kai Wang Quan She Min Li Hongye Zhao Weihong Zhao Bo Chen Jianqing Wu |
| author_sort | Kai Wang |
| collection | DOAJ |
| description | Abstract Lung cancer has one of the highest morbidity and mortality rates in the world. Frailty is common in many countries and is a major cause of premature functional decline and premature death in older adults, and may affect the treatment and prognosis of lung cancer patients. To investigate the predictive value of frailty at diagnosis on all-cause mortality in lung cancer patients, this study retrospectively collected and analysed clinical information on lung cancer patients from 2015–2018. A total of 1667 patients with primary lung cancer were finally included in this study. The median follow-up time of patients was 650 (493, 1001.5) days. A total of 297(17.8%) patients had FI-LAB(the frailty index based on laboratory test) status of frail at the moment of diagnosis and the all-cause mortality rate for all patients was 61.1% (1018/1667). In a univariate model, we found a higher total all-cause mortality risk in frail patients (frail vs. robust, HR(hazard ratio) = 1.616, 95% CI(confidence interval) = 1.349,1.936), after balancing other variables combined into model 1 to model 6. The results were analyzed visually using ROC(Receiver operating characteristic) curves with nomogram and the AUC values ranged from 0.866–0.874. The final inclusion of age, TNM stage, CCI(Charlson comorbidity index) score, surgery history and chemotherapy into a multifactorial model balanced the predictive power of frailty grading on all-cause mortality. The study showed that for lung cancer patients, the higher the level of frailty at diagnosis, the higher the risk of all-cause mortality. In the context of widespread electronic medical records in hospitals, it is convenient and feasible to use FI-LAB to assess the prognosis of lung cancer patients. |
| first_indexed | 2024-04-10T19:41:02Z |
| format | Article |
| id | doaj.art-7d3015265c9244719f912ff2c2a00d4c |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-04-10T19:41:02Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-7d3015265c9244719f912ff2c2a00d4c2023-01-29T12:21:36ZengBMCBMC Geriatrics1471-23182023-01-012311910.1186/s12877-023-03765-wPrognostic significance of frailty status in patients with primary lung cancerKai Wang0Quan She1Min Li2Hongye Zhao3Weihong Zhao4Bo Chen5Jianqing Wu6Jiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Provincial Key Laboratory of Geriatrics, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical UniversityAbstract Lung cancer has one of the highest morbidity and mortality rates in the world. Frailty is common in many countries and is a major cause of premature functional decline and premature death in older adults, and may affect the treatment and prognosis of lung cancer patients. To investigate the predictive value of frailty at diagnosis on all-cause mortality in lung cancer patients, this study retrospectively collected and analysed clinical information on lung cancer patients from 2015–2018. A total of 1667 patients with primary lung cancer were finally included in this study. The median follow-up time of patients was 650 (493, 1001.5) days. A total of 297(17.8%) patients had FI-LAB(the frailty index based on laboratory test) status of frail at the moment of diagnosis and the all-cause mortality rate for all patients was 61.1% (1018/1667). In a univariate model, we found a higher total all-cause mortality risk in frail patients (frail vs. robust, HR(hazard ratio) = 1.616, 95% CI(confidence interval) = 1.349,1.936), after balancing other variables combined into model 1 to model 6. The results were analyzed visually using ROC(Receiver operating characteristic) curves with nomogram and the AUC values ranged from 0.866–0.874. The final inclusion of age, TNM stage, CCI(Charlson comorbidity index) score, surgery history and chemotherapy into a multifactorial model balanced the predictive power of frailty grading on all-cause mortality. The study showed that for lung cancer patients, the higher the level of frailty at diagnosis, the higher the risk of all-cause mortality. In the context of widespread electronic medical records in hospitals, it is convenient and feasible to use FI-LAB to assess the prognosis of lung cancer patients.https://doi.org/10.1186/s12877-023-03765-wFrailtyLung cancerThe frailty index based on laboratory test (FI-LAB)All-cause mortality risk |
| spellingShingle | Kai Wang Quan She Min Li Hongye Zhao Weihong Zhao Bo Chen Jianqing Wu Prognostic significance of frailty status in patients with primary lung cancer BMC Geriatrics Frailty Lung cancer The frailty index based on laboratory test (FI-LAB) All-cause mortality risk |
| title | Prognostic significance of frailty status in patients with primary lung cancer |
| title_full | Prognostic significance of frailty status in patients with primary lung cancer |
| title_fullStr | Prognostic significance of frailty status in patients with primary lung cancer |
| title_full_unstemmed | Prognostic significance of frailty status in patients with primary lung cancer |
| title_short | Prognostic significance of frailty status in patients with primary lung cancer |
| title_sort | prognostic significance of frailty status in patients with primary lung cancer |
| topic | Frailty Lung cancer The frailty index based on laboratory test (FI-LAB) All-cause mortality risk |
| url | https://doi.org/10.1186/s12877-023-03765-w |
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