A Case of Type I Food Allergy Induced by Monosodium Glutamate
Reeko Osada,1 Chiyako Oshikata,1– 3 Yuichi Kurihara,4 Kosuke Terada,1 Yuka Kodama,1 Yuga Yamashita,1 Ryo Nakadegawa,1 Hinako Masumitsu,1 Yuto Motobayashi,1 Hirokazu Takayasu,1 Nami Masumoto,1,3 Saki Manabe,1 Yingyao Zhu,4 Ryo Tanaka,4 Takeshi Kaneko,3 Aya Sasaki,5 Naomi Tsurikisawa1– 3 1Department o...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-03-01
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| Series: | Journal of Asthma and Allergy |
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| Online Access: | https://www.dovepress.com/a-case-of-type-i-food-allergy-induced-by-monosodium-glutamate-peer-reviewed-fulltext-article-JAA |
| _version_ | 1797269811123716096 |
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| author | Osada R Oshikata C Kurihara Y Terada K Kodama Y Yamashita Y Nakadegawa R Masumitsu H Motobayashi Y Takayasu H Masumoto N Manabe S Zhu Y Tanaka R Kaneko T Sasaki A Tsurikisawa N |
| author_facet | Osada R Oshikata C Kurihara Y Terada K Kodama Y Yamashita Y Nakadegawa R Masumitsu H Motobayashi Y Takayasu H Masumoto N Manabe S Zhu Y Tanaka R Kaneko T Sasaki A Tsurikisawa N |
| author_sort | Osada R |
| collection | DOAJ |
| description | Reeko Osada,1 Chiyako Oshikata,1– 3 Yuichi Kurihara,4 Kosuke Terada,1 Yuka Kodama,1 Yuga Yamashita,1 Ryo Nakadegawa,1 Hinako Masumitsu,1 Yuto Motobayashi,1 Hirokazu Takayasu,1 Nami Masumoto,1,3 Saki Manabe,1 Yingyao Zhu,4 Ryo Tanaka,4 Takeshi Kaneko,3 Aya Sasaki,5 Naomi Tsurikisawa1– 3 1Department of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan; 2Department of Allergy and Respirology, Hiratsuka City Hospital, Hiratsuka, Japan; 3Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; 4Department of Dermatology, Hiratsuka City Hospital, Hiratsuka, Japan; 5Department of Clinical Laboratory, Tokyo Dental College Ichikawa General Hospital, Ichikawa, JapanCorrespondence: Naomi Tsurikisawa, Department of Respirology, National Hospital Organization Yokohama Medical Center, 3-60-2 Harajuku, Totsuka-ku, Yokohama, 245-8575, Japan, Tel +81-45-851-2621, Fax +81-45-851-3902, Email User831328@aol.comAbstract: Monosodium glutamate (MSG), a salt form of a non-essential amino acid, is widely used as a food additive, particularly in Asian cuisines, due to its unique flavor-enhancing qualities. Type I allergic reactions to MSG have not previously been reported. Our patient, a 21-year-old woman, was 14 years old when she first noticed swelling of her tongue (but no oral itching, diarrhea, or abdominal pain) after eating various snack foods. Current skin prick testing elicited a weak positive reaction to MSG. We then performed an oral challenge test during which our patient ingested potato snacks. Subsequent histology showed telangiectasia of the buccal mucosa, interstitial edema in the subepithelial submucosa, and mast cell infiltration. Oral mucosal challenge tests using sodium glutamate confirmed oral swelling in this patient. This report is the first to confirm a case of type 1 allergy to MSG by combining pathology findings with the results of challenge testing.Keywords: food additive, mast cell, monosodium glutamate, food allergy |
| first_indexed | 2024-04-25T01:54:18Z |
| format | Article |
| id | doaj.art-7d3319e9a0e64fdaba3585db7bdfa715 |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-04-25T01:54:18Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-7d3319e9a0e64fdaba3585db7bdfa7152024-03-07T17:38:48ZengDove Medical PressJournal of Asthma and Allergy1178-69652024-03-01Volume 1716116591041A Case of Type I Food Allergy Induced by Monosodium GlutamateOsada ROshikata CKurihara YTerada KKodama YYamashita YNakadegawa RMasumitsu HMotobayashi YTakayasu HMasumoto NManabe SZhu YTanaka RKaneko TSasaki ATsurikisawa NReeko Osada,1 Chiyako Oshikata,1– 3 Yuichi Kurihara,4 Kosuke Terada,1 Yuka Kodama,1 Yuga Yamashita,1 Ryo Nakadegawa,1 Hinako Masumitsu,1 Yuto Motobayashi,1 Hirokazu Takayasu,1 Nami Masumoto,1,3 Saki Manabe,1 Yingyao Zhu,4 Ryo Tanaka,4 Takeshi Kaneko,3 Aya Sasaki,5 Naomi Tsurikisawa1– 3 1Department of Respirology, National Hospital Organization Yokohama Medical Center, Yokohama, Japan; 2Department of Allergy and Respirology, Hiratsuka City Hospital, Hiratsuka, Japan; 3Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan; 4Department of Dermatology, Hiratsuka City Hospital, Hiratsuka, Japan; 5Department of Clinical Laboratory, Tokyo Dental College Ichikawa General Hospital, Ichikawa, JapanCorrespondence: Naomi Tsurikisawa, Department of Respirology, National Hospital Organization Yokohama Medical Center, 3-60-2 Harajuku, Totsuka-ku, Yokohama, 245-8575, Japan, Tel +81-45-851-2621, Fax +81-45-851-3902, Email User831328@aol.comAbstract: Monosodium glutamate (MSG), a salt form of a non-essential amino acid, is widely used as a food additive, particularly in Asian cuisines, due to its unique flavor-enhancing qualities. Type I allergic reactions to MSG have not previously been reported. Our patient, a 21-year-old woman, was 14 years old when she first noticed swelling of her tongue (but no oral itching, diarrhea, or abdominal pain) after eating various snack foods. Current skin prick testing elicited a weak positive reaction to MSG. We then performed an oral challenge test during which our patient ingested potato snacks. Subsequent histology showed telangiectasia of the buccal mucosa, interstitial edema in the subepithelial submucosa, and mast cell infiltration. Oral mucosal challenge tests using sodium glutamate confirmed oral swelling in this patient. This report is the first to confirm a case of type 1 allergy to MSG by combining pathology findings with the results of challenge testing.Keywords: food additive, mast cell, monosodium glutamate, food allergyhttps://www.dovepress.com/a-case-of-type-i-food-allergy-induced-by-monosodium-glutamate-peer-reviewed-fulltext-article-JAAfood additivemast cellmonosodium glutamatefood allergy |
| spellingShingle | Osada R Oshikata C Kurihara Y Terada K Kodama Y Yamashita Y Nakadegawa R Masumitsu H Motobayashi Y Takayasu H Masumoto N Manabe S Zhu Y Tanaka R Kaneko T Sasaki A Tsurikisawa N A Case of Type I Food Allergy Induced by Monosodium Glutamate Journal of Asthma and Allergy food additive mast cell monosodium glutamate food allergy |
| title | A Case of Type I Food Allergy Induced by Monosodium Glutamate |
| title_full | A Case of Type I Food Allergy Induced by Monosodium Glutamate |
| title_fullStr | A Case of Type I Food Allergy Induced by Monosodium Glutamate |
| title_full_unstemmed | A Case of Type I Food Allergy Induced by Monosodium Glutamate |
| title_short | A Case of Type I Food Allergy Induced by Monosodium Glutamate |
| title_sort | case of type i food allergy induced by monosodium glutamate |
| topic | food additive mast cell monosodium glutamate food allergy |
| url | https://www.dovepress.com/a-case-of-type-i-food-allergy-induced-by-monosodium-glutamate-peer-reviewed-fulltext-article-JAA |
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