MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites

MMV006087 is a potent Malaria Box compound against Plasmodium falciparum clinical parasites

The emergence of drug-resistant malaria parasites to artemisinin and its partner drugs highlights the need to increase the arsenal of new antimalarials with novel mechanisms of action. To help achieve this aim, this study tested the potency of three Malaria Box compounds (MMV006087, MMV085203, and M...

Full description

Bibliographic Details
Main Authors:	Jersley D. Chirawurah, Bridget Adikah, Felix Ansah, Elizabeth Laryea-Akrong, Harry Danwonno, Collins M. Morang’a, Daniel Dosoo, Lucas Amenga-Etego, Gordon A. Awandare, Yaw Aniweh
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Drug Discovery
Subjects:	antimalarials malaria clinical isolates malaria box compounds artemisinin medicines for malaria venture
Online Access:	https://www.frontiersin.org/articles/10.3389/fddsv.2023.1190471/full

Similar Items

Gossypol is a natural product with good antimalarial activity against Plasmodium falciparum clinical isolates
by: Jersley D. Chirawurah, et al.
Published: (2025-01-01)

Comparative Susceptibility of Plasmodium ovale and Plasmodium falciparum Field Isolates to Reference and Lead Candidate Antimalarial Drugs in Ghana
by: Yaw Aniweh, et al.
Published: (2023-06-01)

Machine learning approaches classify clinical malaria outcomes based on haematological parameters
by: Collins M. Morang’a, et al.
Published: (2020-11-01)

Antimalarial activity of Malaria Box Compounds against Plasmodium falciparum clinical isolates
by: Jersley D. Chirawurah, et al.
Published: (2017-12-01)

Co-infection of Plasmodium falciparum and Schistosoma mansoni is associated with anaemia
by: Sylvester Donne Dassah, et al.
Published: (2023-09-01)

Spatiotemporal analysis of Plasmodium falciparum erythrocyte binding antigen-175 gene dimorphism in Ghana
by: Abraham Y. Kpirikai, et al.
Published: (2025-01-01)

Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity
by: Temitope W. Ademolue, et al.
Published: (2017-04-01)

Recent Advances in the Development of Biosensors for Malaria Diagnosis
by: Francis D. Krampa, et al.
Published: (2020-02-01)

The temporal dynamics of Plasmodium species infection after artemisinin-based combination therapy (ACT) among asymptomatic children in the Hohoe municipality, Ghana
by: Felix Ansah, et al.
Published: (2023-09-01)

Temporal evolution of sulfadoxine-pyrimethamine resistance genotypes and genetic diversity in response to a decade of increased interventions against Plasmodium falciparum in northern Ghana
by: Lucas N. Amenga-Etego, et al.
Published: (2021-03-01)

Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa
by: Saikou Y. Bah, et al.
Published: (2018-11-01)

scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria
by: Collins M. Morang’a, et al.
Published: (2025-01-01)

Stabilization of RDT target antigens present in dried Plasmodium falciparum-infected samples for validating malaria rapid diagnostic tests at the point of care
by: Collins Morang’a, et al.
Published: (2018-01-01)

Plasmodium falciparum Merozoite Associated Armadillo Protein (PfMAAP) Is Apically Localized in Free Merozoites and Antibodies Are Associated With Reduced Risk of Malaria
by: Yaw Aniweh, et al.
Published: (2020-04-01)

Febrile illness diagnostics and the malaria-industrial complex: a socio-environmental perspective
by: Justin Stoler, et al.
Published: (2016-11-01)

Towards ultrasensitive malaria diagnosis using surface enhanced Raman spectroscopy
by: Chen, Keren, et al.
Published: (2018)

Evaluation of a laboratory quality assurance pilot programme for malaria diagnostics in low-transmission areas of Kenya, 2013
by: Elizabeth Wanja, et al.
Published: (2017-05-01)

Recent increase in low complexity polygenomic infections and sialic acid-independent invasion pathways in Plasmodium falciparum from Western Gambia
by: Nora Nghochuzie Nganyewo, et al.
Published: (2023-08-01)

Short-term cryopreservation and thawing have minimal effects on Plasmodium falciparum ex vivo invasion profile
by: Laty G. Thiam, et al.
Published: (2022-09-01)

Urogenital schistosomiasis transmission, malaria and anemia among school-age children in Northern Ghana
by: Sylvester Dassah, et al.
Published: (2022-09-01)

Epidemiology of malaria among pregnant women during their first antenatal clinic visit in the middle belt of Ghana: a cross sectional study
by: David Kwame Dosoo, et al.
Published: (2020-10-01)

Prevalence of chloroquine and antifolate drug resistance alleles in Plasmodium falciparum clinical isolates from three areas in Ghana [version 2; peer review: 2 approved]
by: James Abugri, et al.
Published: (2018-12-01)

Pausing the Fight Against Malaria to Combat the COVID-19 Pandemic in Africa: Is the Future of Malaria Bleak?
by: Nora Nganyewo Nghochuzie, et al.
Published: (2020-06-01)

Modulation of receptor for advanced glycation end products signal transduction pathway as therapeutic option for malaria therapy
by: Chuah, Yaw Kuang
Published: (2015)

Phenotypic characterization of Ghanaian P. falciparum clinical isolates reveals a homogenous parasite population
by: Laty G. Thiam, et al.
Published: (2022-09-01)

Malaria : obstacles and opportunities /
by: Institute of Medicine (U.S.), Committe for the study on malaria prevention and control : status review and atternative strategies, et al.
Published: (1991)

Comparison of leucocyte profiles between healthy children and those with asymptomatic and symptomatic Plasmodium falciparum infections
by: Diana Ahu Prah, et al.
Published: (2020-10-01)

Comparative evaluation of fluorescent in situ hybridization and Giemsa microscopy with quantitative real-time PCR technique in detecting malaria parasites in a holoendemic region of Kenya
by: Joseph Osoga, et al.
Published: (2017-07-01)

Malária grave por Plasmodium falciparum Severe Plasmodium falciparum malaria
by: Andréia Patrícia Gomes, et al.
Published: (2011-09-01)

Zoonotic Malaria: Non-<i>Laverania Plasmodium</i> Biology and Invasion Mechanisms
by: Jing-Wen Hang, et al.
Published: (2021-07-01)

Sensitive Detection of Asymptomatic and Symptomatic Malaria with Seven Novel Parasite-Specific LAMP Assays and Translation for Use at Point-of-Care
by: Kenny Malpartida-Cardenas, et al.
Published: (2023-06-01)

Comparative analysis of asexual and sexual stage Plasmodium falciparum development in different red blood cell types
by: Linda E. Amoah, et al.
Published: (2020-06-01)

Malaria : genetic and evolutionary aspects /
by: Dronamraju, Krishna R., et al.
Published: (2006)

Akta pembasmi malaria, 1971

Malária cerebral no Ceará: relato de caso Cerebral Malaria in Ceará: a case report
by: Marcus Davis Machado Braga, et al.
Published: (2004-02-01)

Two years post affordable medicines facility for malaria program: availability and prices of anti-malarial drugs in central Ghana
by: Alexander Freeman, et al.
Published: (2017-12-01)

Effect of combining mosquito repellent and insecticide treated net on malaria prevalence in Southern Ethiopia: a cluster-randomised trial
by: Wakgari Deressa, et al.
Published: (2014-03-01)

Environmental health risks and benefits of the use of mosquito coils as malaria prevention and control strategy
by: Jonathan N. Hogarh, et al.
Published: (2018-07-01)

Malaria vaccine: A future hope to curtail the global malaria burden
by: Kaliyaperumal Karunamoorthi
Published: (2014-01-01)

Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook
by: Anita Ghansah, et al.
Published: (2019-09-01)