Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy
Background: In breast cancer treatment, aromatase inhibitors (AI) and tamoxifen (Tmx) are frequently used. In this study, the relationship between the hormonal therapy and arthralgia in women with breast cancer was studied. Methods: Sixty-four patients of whom 32 taking AI and 32 taking Tmx were inc...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Cukurova University
2013-02-01
|
| Series: | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| Subjects: | |
| Online Access: | http://www.scopemed.org/fulltextpdf.php?mno=25772 |
| _version_ | 1797908891687714816 |
|---|---|
| author | Gulabi Mese Hakan Sakalli Didem Arslan Tas Abdullah Canataroglu |
| author_facet | Gulabi Mese Hakan Sakalli Didem Arslan Tas Abdullah Canataroglu |
| author_sort | Gulabi Mese |
| collection | DOAJ |
| description | Background: In breast cancer treatment, aromatase inhibitors (AI) and tamoxifen (Tmx) are frequently used. In this study, the relationship between the hormonal therapy and arthralgia in women with breast cancer was studied. Methods: Sixty-four patients of whom 32 taking AI and 32 taking Tmx were included into the study. VAS was used to determine the intensity of pain. Also five options Likert scale was applied to all patients to answer the question “what are your thoughts about the sources of your current pain?”. As laboratory parameters, CBC, BUN creatinine, ALT, AST, alkaline phosphatase, calcium, CRP, ESR, ANA, RF, and estradiol levels of the patients were analyzed. Results: The mean age of the AI group was 52.7 ± 8.2 years and in the Tmx group, it was 47.4 ± 6.5 years (p<0.05). According to Likert scale; the frequency of arthralgia attributed to drug was 43.8 % in AI group and 0 % in tamoxifen group (p<0.05). VAS of AI group (4.7 ± 3.0) was higher than VAS of Tmx group (1.7 ± 2.1) (p<0.05). Serum estradiol level of AI group (16.4 ± 13.2 pg/ml) was found to be lower when compared to that of Tmx group (34.2 ± 21.4 pg/ml) (p<0.05). There were no statistically significant differences between groups for other laboratory parameters (p>0.05, for each). Conclusion: In our study, more frequent and severe arthralgia has been observed in patients under AI treatment when compared to tamoxifen. One of the causes that leads to arthralgia in patients using AI may be low levels of estradiol. [Cukurova Med J 2013; 38(1.000): 78-85] |
| first_indexed | 2024-04-10T11:00:01Z |
| format | Article |
| id | doaj.art-7d345775d3704301a909a528f0dd0ff2 |
| institution | Directory Open Access Journal |
| issn | 0250-5150 |
| language | English |
| last_indexed | 2024-04-10T11:00:01Z |
| publishDate | 2013-02-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Çukurova Üniversitesi Tıp Fakültesi Dergisi |
| spelling | doaj.art-7d345775d3704301a909a528f0dd0ff22023-02-15T16:19:43ZengCukurova UniversityÇukurova Üniversitesi Tıp Fakültesi Dergisi0250-51502013-02-013817885Evaluation of Arthralgia Induced by Aromatase Inhibitor TherapyGulabi MeseHakan SakalliDidem Arslan TasAbdullah CanatarogluBackground: In breast cancer treatment, aromatase inhibitors (AI) and tamoxifen (Tmx) are frequently used. In this study, the relationship between the hormonal therapy and arthralgia in women with breast cancer was studied. Methods: Sixty-four patients of whom 32 taking AI and 32 taking Tmx were included into the study. VAS was used to determine the intensity of pain. Also five options Likert scale was applied to all patients to answer the question “what are your thoughts about the sources of your current pain?”. As laboratory parameters, CBC, BUN creatinine, ALT, AST, alkaline phosphatase, calcium, CRP, ESR, ANA, RF, and estradiol levels of the patients were analyzed. Results: The mean age of the AI group was 52.7 ± 8.2 years and in the Tmx group, it was 47.4 ± 6.5 years (p<0.05). According to Likert scale; the frequency of arthralgia attributed to drug was 43.8 % in AI group and 0 % in tamoxifen group (p<0.05). VAS of AI group (4.7 ± 3.0) was higher than VAS of Tmx group (1.7 ± 2.1) (p<0.05). Serum estradiol level of AI group (16.4 ± 13.2 pg/ml) was found to be lower when compared to that of Tmx group (34.2 ± 21.4 pg/ml) (p<0.05). There were no statistically significant differences between groups for other laboratory parameters (p>0.05, for each). Conclusion: In our study, more frequent and severe arthralgia has been observed in patients under AI treatment when compared to tamoxifen. One of the causes that leads to arthralgia in patients using AI may be low levels of estradiol. [Cukurova Med J 2013; 38(1.000): 78-85]http://www.scopemed.org/fulltextpdf.php?mno=25772Aromatase inhibitorsArthralgiaBreast CancerTamoxifenLikert scale |
| spellingShingle | Gulabi Mese Hakan Sakalli Didem Arslan Tas Abdullah Canataroglu Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy Çukurova Üniversitesi Tıp Fakültesi Dergisi Aromatase inhibitors Arthralgia Breast Cancer Tamoxifen Likert scale |
| title | Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy |
| title_full | Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy |
| title_fullStr | Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy |
| title_full_unstemmed | Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy |
| title_short | Evaluation of Arthralgia Induced by Aromatase Inhibitor Therapy |
| title_sort | evaluation of arthralgia induced by aromatase inhibitor therapy |
| topic | Aromatase inhibitors Arthralgia Breast Cancer Tamoxifen Likert scale |
| url | http://www.scopemed.org/fulltextpdf.php?mno=25772 |
| work_keys_str_mv | AT gulabimese evaluationofarthralgiainducedbyaromataseinhibitortherapy AT hakansakalli evaluationofarthralgiainducedbyaromataseinhibitortherapy AT didemarslantas evaluationofarthralgiainducedbyaromataseinhibitortherapy AT abdullahcanataroglu evaluationofarthralgiainducedbyaromataseinhibitortherapy |