The involvement of TRP channels in bone homeostasis
Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone ser...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00099/full |
| _version_ | 1818272453051285504 |
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| author | Liesbet eLieben Geert eCarmeliet |
| author_facet | Liesbet eLieben Geert eCarmeliet |
| author_sort | Liesbet eLieben |
| collection | DOAJ |
| description | Calcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone serves as a calcium reserve from which calcium is mobilized to maintain normal calcium levels in blood. A negative external calcium balance will therefore at all times impair skeletal integrity. In addition to the external calcium balance, skeletal homeostasis also depends on the proper differentiation and functioning of bone cells, which relies for a large part on intracellular Ca2+ signaling. Members of the transient receptor potential (TRP) family of ion channels affect skeletal homeostasis by mediating processes involved in the extracellular as well as intracellular Ca2+ balance, including intestinal calcium absorption (TRPV6), renal calcium reabsorption (TRPV5), and differentiation of osteoclasts (TRPV1, TRPV2, TRPV4, TRPV5), chondrocytes (TRPV4) and possibly osteoblasts (TRPV1). In this review, we will give a brief overview of the systemic calcium homeostasis and the intracellular Ca2+ signaling in bone cells with special focus on the TRP channels involved in these processes. |
| first_indexed | 2024-12-12T21:42:18Z |
| format | Article |
| id | doaj.art-7d363aecc73d4ac7bf082d5f10a66272 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T21:42:18Z |
| publishDate | 2012-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-7d363aecc73d4ac7bf082d5f10a662722022-12-22T00:11:00ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922012-08-01310.3389/fendo.2012.0009929590The involvement of TRP channels in bone homeostasisLiesbet eLieben0Geert eCarmeliet1Katholieke Universiteit LeuvenKatholieke Universiteit LeuvenCalcium and bone homeostasis are intimately related. On the one hand, bone relies on a sufficient supply of calcium to maintain its structural and mechanical properties and thus largely depends on calcium absorption in the intestine and calcium reabsorption in the kidney. On the other hand, bone serves as a calcium reserve from which calcium is mobilized to maintain normal calcium levels in blood. A negative external calcium balance will therefore at all times impair skeletal integrity. In addition to the external calcium balance, skeletal homeostasis also depends on the proper differentiation and functioning of bone cells, which relies for a large part on intracellular Ca2+ signaling. Members of the transient receptor potential (TRP) family of ion channels affect skeletal homeostasis by mediating processes involved in the extracellular as well as intracellular Ca2+ balance, including intestinal calcium absorption (TRPV6), renal calcium reabsorption (TRPV5), and differentiation of osteoclasts (TRPV1, TRPV2, TRPV4, TRPV5), chondrocytes (TRPV4) and possibly osteoblasts (TRPV1). In this review, we will give a brief overview of the systemic calcium homeostasis and the intracellular Ca2+ signaling in bone cells with special focus on the TRP channels involved in these processes.http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00099/fullCalciumCalcium ChannelsKidneyBoneTRP channelsintestine |
| spellingShingle | Liesbet eLieben Geert eCarmeliet The involvement of TRP channels in bone homeostasis Frontiers in Endocrinology Calcium Calcium Channels Kidney Bone TRP channels intestine |
| title | The involvement of TRP channels in bone homeostasis |
| title_full | The involvement of TRP channels in bone homeostasis |
| title_fullStr | The involvement of TRP channels in bone homeostasis |
| title_full_unstemmed | The involvement of TRP channels in bone homeostasis |
| title_short | The involvement of TRP channels in bone homeostasis |
| title_sort | involvement of trp channels in bone homeostasis |
| topic | Calcium Calcium Channels Kidney Bone TRP channels intestine |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00099/full |
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